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Listar por autor "Claros-Gil, Silvia"
Mostrando ítems 1-20 de 26
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A Novel Human TGF-β1 Fusion Protein in Combination with rhBMP-2 Increases Chondro-Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
Claros-Gil, Silvia; Rico-Llanos, Gustavo Adolfo; Becerra-Ratia, José; Andrades-Gómez, José Antonio (MDPI, 2014)Transforming growth factor-beta (TGF-β) is involved in processes related to the differentiation and maturation of osteoprogenitor cells into osteoblasts. Rat bone marrow (BM) cells were cultured in a collagen-gel containing ... -
Antioxidant and neuroprotective actions of IGF-II against glucocorticoid-induced toxicity in dopaminergic neurons.
Claros-Gil, Silvia; Valverde Moreno, Nadia; Zamorano-González, Pablo; Romero-Zerbo, Silvana Yanina; Lara Fernández, Estrella; Boraldi, Federica; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (2023)The neurodegenerative Parkinson’s disease (PD) affects 1–3% of the population aged over 65. A wide range of pathways and mechanisms are involved in its pathogenesis, such as oxidative stress, mitochondrial dysfunction, ... -
Autologous Human-Derived Bone Marrow Cells Exposed to a Novel TGF-β1 Fusion Protein for the Treatment of Critically Sized Tibial Defect.
Becerra-Ratia, José; Guerado-Parra, Enrique; Claros-Gil, Silvia; Alonso, Mónica; Bertrand, María L; González Plata, Carlos; Andrades-Gómez, José Antonio[et al.] (Taylor & Francis, 2006)We report the first clinical case of transplantation of autologous bone marrow-derived cells in vitro exposed to a novel recombinant human transforming growth factor (rhTGF)-β1 fusion protein bearing a collagen-binding ... -
Bone marrow-derived mesenchymal stem cells transplantation produces a tissue recovery in hydrocephalic mice
García-Bonilla, María; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Claros-Gil, Silvia; Gutiérrez-Pérez, Antonia; Jiménez-Lara, Antonio Jesús[et al.] (2018-07-25)In congenital hydrocephalus, cerebrospinal fluid accumulation is associated to ischemia/hypoxia, metabolic impairment, neuronal damage and astrocytic reaction, which cause significant mortality and life-long neurological ... -
Characterization of adult stem/progenitor cell populations from bone marrow in a three-dimensional collagen gel culture system.
Claros-Gil, Silvia; Rodríguez-Losada, Noela; Cruz, Encarnación; Guerado-Parra, Enrique; Becerra-Ratia, José; Andrades-Gómez, José Antonio[et al.] (Sage Publications, 2012-09-01)Stem cell transplantation therapy using mesenchymal stem cells (MSCs) is considered a useful strategy. Although MSCs are commonly isolated by exploiting their plastic adherence, several studies have suggested that there ... -
Cocaine detrimentally affects mitochondrial functionality and cell viability in dopaminergic neurons.
Zamorano-González, Pablo; Bandini, Luca; Valverde, Nadia; Claros-Gil, Silvia; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Santín-Núñez, Luis Javier; Martín-Montañez, Elisa; Gago-Calderón, Belén; García-Fernández, María Inmaculada[et al.] (2024)An elevated consumption of cocaine (benzoylmethylecgonine), which causes anesthetic and stimulant effects on the central nervous system, may be associated with several neurodegenerative conditions affecting dopaminergic ... -
Composición, morfología y biocompatibilidad de cementos dentales de fosfato de zinc modificados con aditivos de calcio
Arjona-Pulido, Fátima (2018-03-22)Se han preparado y caracterizado biomateriales dentales basados en fosfato de zinc, con el propósito de estudiar los efectos de varios aditivos de calcio en su composición, morfología y bioactividad. Un primer estudio ... -
Effect of bone marrow-derived mesenchymal stem cells on congenital hydrocephalus in the hyh mouse
García-Bonilla, María; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Jiménez, Sebastián; Navarro, Victoria; García-Cuervo, Luisa; Cifuentes-Rueda, Manuel; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Guitérrez, Antonia; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús[et al.] (2017-06-28)Background Bone marrow-derived mesenchymal stem cells (BM-MSC) are considered as a potential therapeutic tool for neurodegenerative diseases due to their ability for migrating into damaged tissue. Additionally, these cells ... -
IGF-II treatment prevents the oxidative damage derived by MPP+/MPTP administration in a cellular and animal model of Parkinson’s disease.
Zamorano-González, Pablo; Valverde, Nadia; Claros-Gil, Silvia; López-González, Manuel Víctor; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Boraldi, Federica; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (2023)El factor de crecimiento de la insulina-II (IGF-II) ha mostrado efectos antioxidantes y neuroprotectores en algunos trastornos neurodegenerativos, como es la Enfermedad de Parkinson (EP). Analizamos el efecto de IGF-II ... -
In Vivo Bioluminescence Imaging of Cell Differentiation in Biomaterials: A Platform for Scaffold Development.
Bagó, Juli R; Aguilar, Elisabeth; Alieva, María; Soler-Botija, Carolina; Vila, Olaia F; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Becerra-Ratia, José; Rubio, Nuria; Blanco, Jerónimo[et al.] (Mary Ann Liebert, 2012-12-19)In vivo testing is a mandatory last step in scaffold development. Agile longitudinal noninvasive real-time monitoring of stem cell behavior in biomaterials implanted in live animals should facilitate the development of ... -
Induction of superficial zone protein (SZP)/ lubricin/PRG 4 in muscle-derived mesenchymal stem/progenitor cells by transforming growth factor-b1 and bone morphogenetic protein-7
Andrades-Gómez, José Antonio; Motaung, Shirley C; Jiménez-Palomo, Pedro; Claros-Gil, Silvia; López-Puerta, José M.; Becerra-Ratia, José; Schmid, Thomas M.; Reddi, A. Hari[et al.] (Springer Nature, 2012-04-10)Introduction Articular cartilage (AC) is an avascular tissue with precise polarity and organization. The three distinct zones are: surface, middle and deep. The production and accumulation of the superficial zone protein ... -
Insulin-like growth factor II neuroprotective effects against mitochondrial-oxidative and neuronal damage induced by CORT and MPP+ in dopaminergic neurons
Claros-Gil, Silvia; Cabrera García, Pablo; Valverde, Nadia; Romero-Zerbo, Silvana Yanina; Lara, Estrella; López-González, Manuel Víctor; Shumilov, Kirill; Rivera-Ramírez, Alicia; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2022-07-12)Aims: Parkinson’s disease (PD) affects 1–3% of the population aged over 65. Stress seems to contribute to PD neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors are oxidative ... -
Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons
Claros-Gil, Silvia; Cabrera, Pablo; Valverde, María; Romero-Zerbo, Silvana Yanina; López-González, Manuel Víctor; Shumilov, Kirill; Rivera-Ramírez, Alicia; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (MDPI, 2021-12-24)Stress seems to contribute to Parkinson’s disease (PD) neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors in this pathophysiology are oxidative stress and mitochondrial ... -
Is the Articular Cartilage Regeneration Approachable Through Mesenchymal Stem Cells Therapies?
López-Puerta, José María; Zamora-Navas, Plácido; Claros-Gil, Silvia; Rico-Llanos, Gustavo Adolfo; Avedillo, Inés; Andrades-Gómez, José Antonio; Becerra-Ratia, José[et al.] (InTech, 2013)oday great hope is set on regenerative medicine in all medical fields. Leland Kaiser introduced the term “Regenerative Medicine” in 1992. He forecasted that a “new branch of medicine will develop that attempts to change ... -
Large-Scale Dendrimer-Based Uneven Nanopatterns for the Study of Local RGD Density Effects on Cell Adhesion
Lagunas, Anna; Castaño, Albert G; Artés, Juan M; Vida-Pol, Yolanda; Collado-Martín, Daniel; Pérez-Inestrosa, Ezequiel; Gorostiza, Pau; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Samitier, Josep[et al.] (2014)Cell adhesion processes are governed by the nanoscale arrangement of the extracellular matrix (ECM), being more affected by local rather than global concentrations of cell adhesive ligands. In many cell-based studies, ... -
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells.
García-Bonilla, María; Ojeda-Pérez, Betsaida; García-Martín, María Luisa; Muñoz-Hernández, María del Carmen; Vitorica, Javier; Jiménez, Sebastián; Cifuentes-Rueda, Manuel; Santos-Ruiz, Leonor; Shumilov, Kirill; Claros-Gil, Silvia; Gutiérrez-Pérez, Antonia; Páez-González, Patricia[et al.] (BMC, 2020-03-17)In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial ... -
New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson's disease
Romero-Zerbo, Silvana Yanina; Valverde, Nadia; Claros-Gil, Silvia; Zamorano-González, Pablo; Boraldi, Federica; Lofaro, Francesco-Demetrio; Lara, Estrella; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (Elsevier, 2024-02-08)Introduction One of the hallmarks of Parkinsońs Disease (PD) is oxidative distress, leading to mitochondrial dysfunction and neurodegeneration. Insulin-like growth factor II (IGF-II) has been proven to have antioxidant ... -
Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy
Villatoro, Antonio J; Fernández, Viviana; Claros-Gil, Silvia; Alcoholado Cueto, Cristina; Cifuentes-Rueda, Manuel; Merayo-Lloves, Jesús; Andrades-Gómez, José Antonio; Becerra-Ratia, José[et al.] (MDPI, 2017)Dry eye syndrome is a complex and insidious pathology with a high level of prevalence among the human population and with a consequently high impact on quality of life and economic cost. Currently, its treatment is ... -
RGD peptide on Dendrimer surfaces Affects Mesenchymal Stem Cells Adhesion
Vida-Pol, Yolanda; Molina, Noemi; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Lagunas, Anna; Claros-Gil, Silvia; Becerra-Ratia, José; Andrades-Gómez, José Antonio; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (2016-04-07)Mesenchymal stem cells (MSCs) are promising candidates for a range of tissue regeneration applications. Adequate scaffolds are necessary for their application in vivo, where interactions between cells and the surface ... -
Role of Insulin-Growth Factor II on mitochondrial recovery in a cellular model of Parkinson's Disease
Valverde, Nadia; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Claros-Gil, Silvia; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (Journal of Physiology and Biochemistry, 2022-09)Insulin-growth factor II (IGF-II) has shown antioxidant and neuroprotective effects in some neurodegenerative disorders. ROS causes damage to cellular macromolecules affecting several cellular processes and resulting in ...