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Listar por autor "León-Rodríguez, Ana"
Mostrando ítems 1-6 de 6
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Anxiety and mild microglial activation in the amygdala two weeks after NA-induced neuroinflammation
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Pedraza-Benítez, María del Carmen; Mateos-Grondona, Jesús; López-Ávalos, María Dolores; León-Rodríguez, Ana[et al.] (Wiley Periodicals, LLC, 2021-07)A single injection of neuraminidase (NA) within the cerebral ventricles (ICV) triggers an acute neuroinflammation. Neurological complications or behavioral alterations have been associated to neuroinflammation. While some ... -
Enhanced stress response in rats that suffered acute neuroinflammation induced by neuraminidase three months before
León-Rodríguez, Ana; Mateos-Grondona, Jesús; Fernández-Arjona, María del Mar; Pedraza-Benítez, María del Carmen; López-Ávalos, María Dolores (2022)Microglial cells are protagonists in neuroinflammatory processes and their activation is a notorious feature of such events. In acute inflammation, microglial cells return to their basal surveillant state in few days. ... -
Long-term priming of hypothalamic microglia is associated with energy balance disturbances under diet-induced obesity
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (Wiley, 2022-05-22)Exposure of microglia to an inflammatory environment may lead to their priming and exacerbated response to future inflammatory stimuli. Here we aimed to explore hypothalamic microglia priming and its consequences on energy ... -
Neuraminidase-induced neuroinflammation causes anxiety and microgliosis in the amygdala
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Pedraza-Benítez, María del Carmen; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (2021)An intracerebroventricular (ICV) injection of neuraminidase (NA) within the lateral ventricles originates an acute event of neuroinflammation, which is solved to a great extent after two weeks. Recently, neurological ... -
Partial inhibition of CSF1R signaling reverses long-term microglial priming.
Microglial cells are main actors in acute neuroinflammation, during which they activate to later return to a basal resting state. Sometimes they retain immune memory of previous neuroinflammatory events, turning into ... -
Primed microglia after acute neuroinflammation may drive an enhanced stress response.
López-Ávalos, María Dolores; Pedraza-Benítez, María del Carmen; Mateos-Grondona, Jesús; Fernández-Arjona, María del Mar; León-Rodríguez, Ana (2023)Microglial cells become activated during acute neuroinflammation and usually they return to their basal surveillant state in a few days. However, sometimes microglia evolve towards a primed state characterized by an ...