Listar por autor "León-Rodríguez, Ana"
Mostrando ítems 1-9 de 9
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Anxiety and mild microglial activation in the amygdala two weeks after NA-induced neuroinflammation
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Pedraza-Benítez, María del Carmen
; Mateos-Grondona, Jesús; López-Ávalos, María Dolores; León-Rodríguez, Ana[et al.] (Wiley Periodicals, LLC, 2021-07)
A single injection of neuraminidase (NA) within the cerebral ventricles (ICV) triggers an acute neuroinflammation. Neurological complications or behavioral alterations have been associated to neuroinflammation. While some ... -
Anxiety‑like behavior and microglial activation in the amygdala after acute neuroinflammation induced by microbial neuraminidase.
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Pedraza-Benítez, María del Carmen; López-Ávalos, María Dolores (Springer Nature, 2022-07-08)
Short-term behavioral alterations are associated with infection and aid the recovery from sickness. However, concerns have raised that sustained behavioral disturbances after acute neuroinflammation could relate to ... -
Enhanced stress response in rats that suffered acute neuroinflammation induced by neuraminidase three months before
León-Rodríguez, Ana; Mateos-Grondona, Jesús; Fernández-Arjona, María del Mar; Pedraza-Benítez, María del Carmen; López-Ávalos, María Dolores (2022)
Microglial cells are protagonists in neuroinflammatory processes and their activation is a notorious feature of such events. In acute inflammation, microglial cells return to their basal surveillant state in few days. ... -
Long-term priming of hypothalamic microglia is associated with energy balance disturbances under diet-induced obesity
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (Wiley, 2022-05-22)
Exposure of microglia to an inflammatory environment may lead to their priming and exacerbated response to future inflammatory stimuli. Here we aimed to explore hypothalamic microglia priming and its consequences on energy ... -
Long-term reprogramming of primed microglia after moderate inhibition of CSF1R signaling.
León-Rodríguez, Ana; Mateos-Grondona, Jesús; Marín Wong, Sonia; López-Aranda, Manuel Francisco; López-Ávalos, María Dolores (Wiley, 2024)
In acute neuroinflammation, microglia activate transiently, and return to a resting state later on. However, they may retain immune memory of such event, namely priming. Primed microglia are more sensitive to new stimuli ... -
Microglia activated by microbial neuraminidase contributes to ependymal cell death.
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; López-Ávalos, María Dolores; Mateos-Grondona, Jesús (Springer Nature, 2021-03-23)
The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model. ... -
Neuraminidase-induced neuroinflammation causes anxiety and microgliosis in the amygdala
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Pedraza-Benítez, María del Carmen; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (2021)
An intracerebroventricular (ICV) injection of neuraminidase (NA) within the lateral ventricles originates an acute event of neuroinflammation, which is solved to a great extent after two weeks. Recently, neurological ... -
Partial inhibition of CSF1R signaling reverses long-term microglial priming.
Microglial cells are main actors in acute neuroinflammation, during which they activate to later return to a basal resting state. Sometimes they retain immune memory of previous neuroinflammatory events, turning into ... -
Primed microglia after acute neuroinflammation may drive an enhanced stress response.
López-Ávalos, María Dolores; Pedraza-Benítez, María del Carmen; Mateos-Grondona, Jesús; Fernández-Arjona, María del Mar; León-Rodríguez, Ana (2023)
Microglial cells become activated during acute neuroinflammation and usually they return to their basal surveillant state in a few days. However, sometimes microglia evolve towards a primed state characterized by an ...