Listar por autor "Leiva Rebollo, Rocío"
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An Efficient Machine Learning Method to Identify Genetic Drivers of Avian Influenza Virus Adaptation to Humans
Leiva Rebollo, Rocío; Patiño Galindo, Juan; Villalon Letelier, Fernando; Mena, Nacho; Tansey, W; Park, K; Labella Vera, Alejandro Manuel; Castro-López, María Dolores
; Borrego-García, Juan José; Rabadán, Raúl; García Sastre, Adolfo[et al.] (2024-09-02)
In this work we developed a method, based on a logistic regression model, to identify mutations subject to directional selection. We tested the model analyzing thousands of AIV (H5N1, H7N9) sequences from public datasets, ... -
Analysis of gene expression in nodavirus-inoculated Senegalese sole using a new Openarray® platform.
Labella Vera, Alejandro Manuel; Gémez Mata, Juan; Vera, Isabel; Bandin, Isabel; Leiva Rebollo, Rocío; Borrego-García, Juan José; García-Rosado, Esther[et al.] (Elsevier, 2019)
Nervous necrosis virus (NNV) is the causative agent of the viral encephalopathy and retinopathy, a disease that affects cultured Senegalese sole (Solea senegalensis). A NNV reassortant (Ss160.03), combining genomic segments ... -
Capsid amino acids at positions 247 and 270 are involved in the virulence of betanodaviruses to European sea bass
Moreno García, Patricia; Souto-Pereira, Sandra; Leiva Rebollo, Rocío; Bandín Matos, Isabel; Alonso-Sánchez, María del Carmen (Springer Nature, 2019-10-19)
European sea bass (Dicentrarchus labrax) is severely afected by nervous necrosis disease, caused by nervous necrosis virus (NNV). Two out of the four genotypes of this virus (red-spotted grouper nervous necrosis virus, ... -
Cytokine-like activity of European sea bass ISG15 protein on RGNNV-infected E−11 cells
Moreno García, Patricia; Leiva Rebollo, Rocío; García Rosado, Esther; Béjar-Alvarado, Julia; Alonso-Sánchez, María del Carmen (Elsevier, 2022-08-18)
IFN-I generates an antiviral state by inducing the expression of numerous genes, called IFN-stimulated genes, ISGs, including ISG15, which is the only ISG with cytokine-like activity. In a previous study, we developed ... -
Evaluation of Gilthead Seabream (Sparus aurata) Immune Response after LCDV-Sa DNA Vaccination
Leiva Rebollo, Rocío; Castro-López, María Dolores; Moreno García, Patricia; Borrego-García, Juan José; Labella Vera, Alejandro Manuel (MDPI, 2021-05-29)
Lymphocystis disease is the main viral pathology in gilthead seabream aquaculture. Currently, there are no treatments or vaccines to control this disease, thus our main goal was to construct a DNA vaccine that can be used ... -
Fish Iridoviridae: infection, vaccination and immune response
Leiva Rebollo, Rocío; Labella Vera, Alejandro Manuel; Gémez Mata, Juan; Castro-López, María Dolores; Borrego García, Juan José (Springer Nature, 2024-07-15)
Each year, due to climate change, an increasing number of new pathogens are being discovered and studied, leading to an increase in the number of known diseases affecting various fish species in different regions of the ... -
Identification, resistance to antibiotics and biofilm formation of bacterial strains isolated from a reverse osmosis system of a drinking water treatment plant
(Elsevier, 2021-02-04)Membrane processes such as, reverse osmosis (RO), is one option for drinking water treatment where a high product quality is desired. RO membranes are able to effectively remove organic and inorganic compounds and ... -
Immune gene expression in gilthead seabream (Sparus aurata) after Lymphocystis disease virus (LCDV‐Sa) challenge resulting in asymptomatic infection
Leiva Rebollo, Rocío; Labella Vera, Alejandro Manuel; Borrego-García, Juan José; Castro-López, María Dolores (Oxford Academic, 2020-01-01)
Aims: To determine the immune gene expression response of gilthead seabream (Sparus aurata) that is experimentally infected with the lymphocystivirus LCDV-Sa. Methods and Results: Viral DNA and transcripts were detected ... -
Immune response of DNA vaccinated-gilthead seabream (Sparus aurata) against LCDV-Sa infection: relevance of the inflammatory process
Leiva Rebollo, Rocío; Gémez Mata, Juan; Castro-López, María Dolores; Borrego García, Juan José; Labella Vera, Alejandro Manuel (Frontiers, 2023-06-06)
Lymphocystis disease is one of the main viral pathologies affecting cultured gilthead seabream (Sparus aurata) in the Mediterranean region. Recently, we have developed a DNA vaccine based on the major capsid protein (MCP) ... -
Lymphocystis disease virus (LCDV-Sa), polyomavirus 1 (SaPyV1) and papillomavirus 1 (SaPV1) in samples of Mediterranean gilthead seabream
Labella Vera, Alejandro Manuel; Leiva Rebollo, Rocío; Ali, Aleja; Borrego-García, Juan José (Inter-Research Science Publisher, 2019-01-10)
Lymphocystis disease, caused by the iridovirus lymphocystis disease virus (LCDV), is characterized by the appearance of tumour-like lesions on the skin of affected animals associated with several environmental factors ... -
Persistence of Lymphocystis Disease Virus (LCDV) in Seawater
Leiva Rebollo, Rocío; Labella Vera, Alejandro Manuel; Jiménez Valverde, Estefanía; Castro-López, María Dolores; Borrego-García, Juan José (Springer Link, 2020-02-21)
Lymphocystis disease virus (LCDV), the causative agent of lymphocystis disease (LCD), is a waterborne pathogen that uses the external surfaces, including the gills, as portals to gain access to fsh host. However, there ...