Listar por autor "Izquierdo, Guillermo"
Mostrando ítems 1-7 de 7
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Effectiveness of glatiramer acetate compared to other multiple sclerosis therapies
Izquierdo, Guillermo; García-Agua-Soler, Nuria
; García-Ruiz, Antonio J.; Rus, Macarena (Wiley, 2015)
Objective: To assess the effectiveness of glatiramer acetate (GA) compared to other multiple sclerosis (MS) therapies in routine clinical practice. Materials and methods: Observational cohort study carried out in MS ... -
Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1
Matesanz, Fuencisla; González-Pérez, Antonio; Lucas, Miguel; Sanna, Serena; Gayán, Javier; Urcelay, Elena; Zara, Ilenia; Pitzalis, Maristella; Cavanillas, María L; Arroyo, Rafael; Zoledziewska, Magdalena; Marrosu, Marisa; Fernández Fernández, Óscar; Leyva-Fernández, Laura; Alcina, Antonio; Fedetz, María; Moreno-Rey, Concha; Velasco, Juan; Real, Luis M.; Ruiz-Peña, Juan Luis; Cucca, Francesco; Ruiz, Agustín; Izquierdo, Guillermo; Matesanz[et al.] (Public Library of Science, 2012)
Multiple Sclerosis (MS) is the most common progressive and disabling neurological condition affecting young adults in the world today. From a genetic point of view, MS is a complex disorder resulting from the combination ... -
Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis.
Alcina, Antonio; Fedetz, María; Fernández, Óscar; Saiz, Albert; Izquierdo, Guillermo; Lucas, Miguel; Leyva-Fernández, Laura; García-León, Juan Antonio; Abad-Grau, María del Mar; Alloza, Iraide; Antigüedad, Alfredo; Garcia-Barcina, María Jesús; Vandenbroeck, Koen; Varadé, Jezabel; de la Hera, Belén; Arroyo, Rafael; Comabella, Manuel; Montalban, Xavier; Petit-Marty, Natalia; Navarro, Arcadi; Otaegui, David; Olascoaga, Javier; Blanco, Yolanda; Urcelay, Elena; Matesanz, Fuencisla[et al.] (BMJ Journals, 2013-01)
Background and aim: Several studies have highlighted the association of the 12q13.3-12q14.1 region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple sclerosis (MS); however, the causal variants ... -
IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).
Alcina, Antonio; Fedetz, María; Ndagire, Dorothy; Fernández Fernández, Óscar; Leyva-Fernández, Laura; Guerrero, Miguel; Abad-Grau, María del Mar; Arnal, Carmen; Delgado, Concepción; Lucas, Miguel; Izquierdo, Guillermo; Matesanz, Fuencisla[et al.] (Public Library of Science, 2009)
Background:IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity. Methods and Results: Here we perform a replication and ... -
Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations
Kristjansdottir, G; Sandling, JK; Bonetti, A; Roos, IM; Milani, L; Wang, C; Gustafsdottir, SM; Sigurdsson, S; Lundmark, A; Tienari, PJ; Koivisto, K; Elovaara, I; Pirttilä, T; Reunanen, M; Peltonen, L; Saarela, J; Hillert, J; Olsson, T; Landegren, U; Alcina, Antonio; Fernández Fernández, Óscar; Leyva-Fernández, Laura; Guerrero, Miguel; Lucas, Miguel; Izquierdo, Guillermo; Matesanz, Fuencisla; Syvänen, A-C[et al.] (BMJ, 2008)
Background: IRF5 is a transcription factor involved both in the type I interferon and the toll-like receptor signalling pathways. Previously, IRF5 has been found to be associated with systemic lupus erythematosus, rheumatoid ... -
The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis.
Alcina, Antonio; Vandenbroeck, Köen; Otaegui, David; Saiz, Alberto; González, José Ramón; Fernández Fernández, Óscar; Cavanillas, María L; Cénit, María C; Arroyo, Rafael; Alloza, Iraide; Garcia-Barcina, María; Antigüedad, Alfredo; Leyva-Fernández, Laura; Izquierdo, Guillermo; Lucas, Miguel; Fedetz, María; Pinto-Medel, María Jesús; Olascoaga, Javier; Blanco, Yolanda; Comabella, Manuel; Montalbán, Xavier; Urcelay, Elena; Matesanz, Fuencisla[et al.] (Springer Nature, 2010)
Genome-wide association studies (GWAS) have revealed that different diseases share susceptibility variants. Twelve single- nucleotide polymorphisms (SNPs) previously associated with different immune-mediated diseases in ... -
The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis.
Matesanz, Fuencisla; Fernández-Fernández, Óscar; Milne, Roger L.; Fedetz, María; Leyva-Fernández, Laura; Guerrero, Miguel; Delgado, Concepción; Lucas, Miguel; Izquierdo, Guillermo; Alcina, Antonio[et al.] (Elsevier, 2008)
Some polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case–control study of three ...