Listar por autor "Pérez-Pomares, José María"
Mostrando ítems 1-20 de 28
-
A developmental model for the pathogenenesis of cardiac arterio-ventricular fistulae
Palmquist-Gomes, Paul; Martín-Robles, José Carlos; Cano-Ballesteros, Sara; Guadix-Domínguez, Juan Antonio
; Pérez-Pomares, José María (2017-03-06)
Coronary Artery Fistulae (CAF) are congenital coronary artery (CA) anomalies consisting of an abnormal communication of a coronary artery with either a cardiac chamber or a large cardiac vessel. Although their incidence ... -
A Turn-On Two-Photon Fluorescent Probe for Detecting Lysosomal Hydroxyl Radicals in Living Cells.
Benítez-Martín, Carlos; Guadix-Domínguez, Juan Antonio; Pearson, John; Nájera-Albendín, Francisco; Pérez-Pomares, José María; Perez-Inestrosa, Ezequiel[et al.] (Elsevier, 2019)
The detection of reactive oxygen species (ROS) in biological systems and its imaging is of great importance. Among them, the hydroxyl radical (radical dotOH) stands out as one of the most reactive, playing an important ... -
Avian embryonic coronary arterio-venous patterning requires the contribution of different endothelial cell populations
Coronary blood vessels irrigate the heart muscle and are crucial to late embryonic and adult heart function. Despite the developmental significance and clinical relevance of coronary vasculature, the embryonic origin as ... -
Characterization of epicardial-derived cardiac interstitial cells: differentiation and mobilization of heart fibroblast progenitors
The non-muscular cells that populate the space found between cardiomyocyte fibers are known as 'cardiac interstitial cells' (CICs). CICs are heterogeneous in nature and include different cardiac progenitor/stem cells, ... -
Coup-TFII expression defines two different septum transversum cell compartments crucial to cardiac septation and compact ventricular wall growth
Guadix-Domínguez, Juan Antonio; Pires-Gomes, Adriana; Cano-Ballesteros, Sara; Pogontke, Cristina; Palmquist-Gomes, Paul; Rojas, Anabel; Pérez-Pomares, José María[et al.] (2018-11-29)
COUP-TFII encodes for an orphan nuclear receptor expressed by multiple embryonic tissues. COUP-TFII functions include the regulation of mesodermal progenitor differentiation and cell fate specification, and is required for ... -
Detecting hydroxyl radical with a new two-photon fluorescent probe in living cells
Nájera-Albendín, Francisco; Benítez-Martín, Carlos; Guadix-Domínguez, Juan Antonio; Pérez-Pomares, José María; Pérez-de-Inestrosa-Villatoro, Ezequiel (Real Sociedad Española de Química, 2018-06-20)
Reactive oxygen species (ROS) are known to be involved in the onset and development of multiple diseases, including cancer, cardiovascular diseases, neurodegenerative diseases and diabetes among others. Generation of ROS ... -
Developmental bases of cardiac vascularization and regeneration
(UMA Editorial, 2020)En esta tesis doctoral se estudian los fenómenos de vascularización y regeneración del corazón en un contexto embrionario usando embriones de ave (codorniz, pollo y pato) y ratón (usando varias líneas transgénicas) como ... -
Dissecting the role of micro-RNA200B in epicardial-derived cell diversification and migration
Simón Fernández, S; Domínguez, JN; Vilches, JM; Hernández Torres, F; Ramírez Acuña, F; Carmona, R; Guadix-Domínguez, Juan Antonio; Pérez-Pomares, José María; Muñoz-Chápuli-Oriol, Ramón; Franco, D; Aránega, AE[et al.] (2018-11-20)
Mostramos como miR200B se expresa en los estadios E12.5 y E15.5 durante el desarrollo cardiaco, en concreto en una subpoblación de células derivadas del epicardio. Experimentos de pérdida y ganancia de función muestran que ... -
Epicardial development revisited: proepicardial heterogeneity.
(UMA Editorial, 2024)Las células epiteliales epicárdicas y las células mesenquimales derivadas de epicardio son fundamentales para el desarrollo del corazón embrionario. Su contribución a la formación del intersticio cardiaco, mediante la ... -
Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio-venous connections
Cano, Elena; Carmona-Mejías, Rita María; Ruiz-Villalba, Adrián; Rojas, Anabel; Chau, You-Ying; Wagner, Kay-Dietrich; Wagner, Nicole; Hastie, Nicholas D.; Muñoz-Chápuli-Oriol, Ramón; Pérez-Pomares, José María[et al.] (Proceedings of the National Academy of Sciences (PNAS), 2016-01)
Recent reports suggest that mammalian embryonic coronary endothelium (CoE) originates from the sinus venosus and ventricular endocardium. However, the contribution of extracardiac cells to CoE is thought to be minor and ... -
FSP1/S100A4 delineates distinct cardiac cell populations
(UMA Editorial, 2021)El objetivo principal de este proyecto es estudiar el desarrollo embrionario y la diferenciación de los progenitores fibroblásticos del corazón, así como analizar la regulación celular y molecular de la fibrosis durante ... -
Imagen-Sección histológica del pulmón de un embrión de pollo de doce días de incubación
Carmona-Mejías, Rita María; Pérez-Pomares, José María (Universidad de Málaga, Facultad de Ciencias, 2011)
-
In vivo and In vitro cartilage differentiation from embryonic epicardial progenitor cells
Marín-Sedeño, Ernesto; Ruiz-Villalba, Adrián; Palmquist-Gomes, Paul; Sánchez Tévar, Ana María; Rico-Llanos, Gustavo Adolfo; Pérez-Pomares, José María; Guadix-Domínguez, Juan Antonio[et al.] (2022)
The presence of cartilage tissue in embryonic and adult hearts of various vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac ... -
Indolenine-Based Derivatives as Customizable Two-Photon Fluorescent Probes for pH Bioimaging in Living Cells
Benítez-Martín, Carlos; Guadix-Domínguez, Juan Antonio; Pearson, John; Nájera-Albendín, Francisco; Pérez-Pomares, José María; Perez-Inestrosa, Ezequiel[et al.] (American Chemical Society, 2020)
Novel pH probes based on 2-(6-methoxynaphthalen-2-yl)-3,3-dimethyl3H-indole have been synthesized and characterized. These compounds display excellent “off−on” fluorescence responses to acidic pH especially under two-photon ... -
Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells form myocardial infarction scar
Ruiz-Villalba, Adrián; Simon, Ana María; Pogontke, Cristina; Castillo, Maria I; Abizanda, Gloria; Pelacho, Beatriz; Sanchez-Dominguez, Rebeca; Segovia, Jose C; Prósper, Felipe; Pérez-Pomares, José María[et al.] (2015-05)
Background: Although efforts continue to find new therapies to regenerate infarcted heart tissue, knowledge of the cellular and molecular mechanisms involved remains poor. Objectives: This study sought to identify the ... -
La expresión miocárdica del gen supresor del tumor de Wilms (Wt1) es esencial para el desarrollo cardíaco y reaparece en cardiomiocitos adultos
Carmona-Mejías, Rita María; Ariza Medina, Laura Maria; Guadix-Domínguez, Juan Antonio; Torrado, Mario; Mikhailov, Alexander; Pérez-Pomares, José María; Muñoz-Chápuli-Oriol, Ramón[et al.] (2017-12-18)
El gen supresor del tumor de Wilms, Wt1, codifica un factor de transcripción del tipo “dedos de zinc” implicado en transcripción, regulación post-transcripcional e interacciones proteína-proteína. La función de este gen ... -
La expresión miocárdica del gen supresor del tumor de Wilms(Wt1) es esencial para el desarrollo cardiaco
Muñoz-Chápuli-Oriol, Ramón; Carmona-Mejías, Rita María; Ariza Medina, Laura Maria; Cañete, Ana; Torrado, Mario; Mikhailov, Alexander; Pérez-Pomares, José María[et al.] (2018-11-09)
El gen supresor del tumor de Wilms,Wt1, codifica un factor de transcripción del tipo “dedos de zinc” implicado en transcripción, regulación post-transcripcional e interacciones proteína-proteína. Durante el desarrollo ... -
El más complejo de los viajes : el embrión en la sociedad contemporánea
Pérez-Pomares, José María (UMA / SEDOC, 2010)
La palabra embrión evoca en nosotros, de forma inmediata, extrañas y misteriosas imágenes de probetas y laboratorios. Sin duda no deja de ser una paradoja sorprendente que aquello que todos nosotros hemos sido alguna vez, ... -
Medallas ganadas en el campo de la batalla inmune
Pérez-Pomares, José María (Universidad de Málaga, Facultad de Ciencias, 2011)
-
Myocardial infarction ´through the window´: dual dynamics for cardiac fibroblasts activation
Ruiz-Villalba, Adrián; Hernández, Silvia C.; Ainciburu, Marina; Vilas-Zornoza, Amaia; Sudupe, Laura; Sarvide, Sarai; Planell, Nuria; Ripalda-Cemboráin, Purificación; Abizanda, Gloria; Pérez-Pomares, José María; Gómez-Cabrero, David; Prósper, Felipe[et al.] (2022)
Activated cardiac fibroblasts (CFs) are responsible for the healing of the heart tissue after a myocardial infarction (MI). Based on high throughput technologies, several groups have recently demonstrated their heterogeneity ...