Listar por autor "Pérez-Martín, Margarita"
Mostrando ítems 1-20 de 30
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A model of neuroinflammation and demyelination by intracerebroventricular injection of microbial neuraminidase
Fernández-Llebrez, Pedro
; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Mateos-Grondona, Jesús; Rodriguez-de-Fonseca, Fernando; López-Ávalos, María Dolores[et al.] (2014-07-14)
Neuraminidase from Clostridium perfringens, which cleaves terminal sialic acid from carbohydrate chains, was injected in the lateral ventricle of rats. It diffused in the ipsilateral ventricle, the third ventricle, and ... -
Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test
Moreno-Fernández, Román D.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; García-Fernández, María Inmaculada; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2016-07-20)
Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ... -
The absence of LPA1 receptor results in lipidome dysregulation and Neuropeptide-Y underexpression
Tabbai-Amal, Sara; Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; Fernández, María; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2018-07-18)
LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signaling molecule. It has been shown that the LPA1 receptor is involved in ... -
Acute psychological stress: effects on hippocampal neurogenesis and the role of microglia
Nieto-Quero, Andrea; Chaves-Peña, Patricia; Infantes-López, M. Inmaculada; Zambrana-Infantes, Emma; Tabbai-Amal, Sara; Muñoz-Martín, José; Pérez-Martín, Margarita; Pedraza-Benítez, María del Carmen[et al.] (2022)
Among all the factors that can contribute to the onset of psychopathological disorders, stress is the main environmental factor. The hippocampus is one of the most sensitive regions to the harmful effects of stress, in ... -
Dataset Orbitrap Raw-Data Stress Hippocampus(1h-24h)
Nieto-Quero, Andrea; Infantes-López, M. Inmaculada; Pedraza-Benítez, María del Carmen; Pérez-Martín, Margarita (Universidad de Málaga, 2023-03-30)
We have examined the effect of an acute stress in the proteomic profile of hippocampus. For this purpose, to extract information from proteomic profiles (1 and 24 hours post-acute stress) a Quadrupole-Orbitrap mass ... -
Dataset Orbitrap Raw-Data Stress Hypothalamus(1h-24h)
Infantes-López, M. Inmaculada; Nieto-Quero, Andrea; Pérez-Martín, Margarita; Pedraza-Benítez, María del Carmen (Universidad de Málaga, 2023-03-30)
We have examined the effect of an acute stress in the proteomic profile of hypothalamus. For this purpose, to extract information from proteomic profiles (1 and 24 hours post-acute stress) a Quadrupole-Orbitrap mass ... -
Determinación de las especies de LPA en hipocampo de ratón. Efecto de diferentes protocolos de estrés
(UMA Editorial, 2020)El LPA es un lípido bioactivo que está involucrado en la señalización intracelular a través de los seis receptores acoplados a proteínas G (LPA1-6). Entre estos receptores, LPA1 es un fuerte candidato para mediar los efectos ... -
Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models
Nieto-Quero, Andrea; Chaves-Peña, Patricia; Santín-Núñez, Luis Javier; Pérez-Martín, Margarita; Pedraza-Benítez, María del Carmen (ELSEVIER, 2021-11)
Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain ... -
Efectos del estrés sobre comportamientos de tipo depresivo, la microglía y la neurogénesis hipocampal. Papel del sistema LPA endógeno
(UMA Editorial, 2022)El estrés constituye el principal factor ambiental en la etiología de los trastornos psicopatológicos, entre ellos la depresión. El hipocampo es una de las regiones más sensibles a los efectos nocivos del estrés, pudiendo ... -
Effects of chronic stress on hippocampal microglia and neurogenesis of mice under social defeat stress.
Muñoz-Martín, José; Infantes-López, M. Inmaculada; Chaves-Peña, Patricia; Nieto-Quero, Andrea; Zambrana-Infantes, Emma; Pedraza-Benítez, María del Carmen; Pérez-Martín, Margarita[et al.] (2022-07)
Introduction: Chronic stress is the main environmental factor in the aetiology of depression and it is known that this type of stress may cause alterations in brain regions such as the hippocampus. Nevertheless, changes ... -
Effects on the hippocampal microglia after acute treatment of a psychological stressor associated with depressive-like behaviours
Nieto-Quero, Andrea; Infantes-López, M. Inmaculada; Zambrana-Infantes, Emma; Chaves-Peña, Patricia; Tabbai-Amal, Sara; Pérez-Martín, Margarita; Pedraza-Benítez, María del Carmen[et al.] (2021-07)
Stressful life events may have a negative impact on mental health compromising people's well-being, so knowing the neurobiological changes that occur after psychosocial stressors can have an impact on overall health. ... -
Female microglia and neurogenesis respond differently to social defeat stress compared to males.
Infantes-López, María Inmaculada; Zambrana-Infantes, Emma; Chaves-Peña, Patricia; Nieto-Quero, Andrea; Muñoz-Martín, José; Zea-Doña, Alejandro; Pedraza-Benítez, María del Carmen; Pérez-Martín, Margarita[et al.] (2024)
Depression is a concerning public health threat highly associated with stress. Stress increases brain immune alterations, namely in microglia, which can affect neuron physiology, like neurogenesis, causing a depressive-like ... -
Gut microbiome specific changes in different behavioral profiles in a mouse social defeat stress model.
Infantes-López, M. Inmaculada; Domínguez-Maqueda, Marta; Cerezo Ortega, Isabel M.; Zambrana-Infantes, Emma; Moriñigo-Gutiérrez, Miguel Ángel; Pedraza-Benítez, María del Carmen; Pérez-Martín, Margarita[et al.] (2023)
The gut microbiome has arisen as one important modulator of general health, including brain function. In fact, disturbances in brain health are commonly mirrored in the microbiome, which could be contributing to pathology. ... -
Hippocampal neurogenesis changes in a sex and region-specific manner in adult mice subjected to maternal separation as an early life stress.
Muñoz-Martín, José; Chaves-Peña, Patricia; Infantes-López, María Inmaculada; Zambrana-Infantes, Emma; Nieto-Quero, Andrea; Carayol-Gordillo, Virginia; Martín-Aguiar, Víctor; Zea-Doña, Alejandro; Pedraza-Benítez, María del Carmen; Pérez-Martín, Margarita[et al.] (2024)
Introduction: Early life stress (ELS) might produce long lasting changes in hippocampal neurogenesis and increase the vulnerability to stress-related disorders later in adulthood. Objective: The analysis of immature granule ... -
IGF-I stimulates cell proliferation in a specific area of the hypothalamic wall
Pérez-Martín, Margarita; Cifuentes-Rueda, Manuel; Mateos-Grondona, Jesús; López-Ávalos, María Dolores; Fernández-Llebrez, Pedro (2015-09-15)
Neurogenesis in the adult rat hippocampal subgranular zone and the subventricular zone of the lateral ventricles has been well documented. Increasing evidence suggests that neurogenesis also occurs in the adult hypothalamus. ... -
Influence of preinfarction angina on the release kinetics of endothelial progenitor cells and cytokines during the week after infarction
Jiménez-Navarro, Manuel Francisco; Caballero-Borrego, Juan; Rodríguez-Losada, Noela; Cabrera-Bueno, Fernando; Marchal, Juan Antonio; Estebaranz, Javier; Muñoz-García, Antonio Jesús; Perán-Quesada, Macarena; Pérez-Martín, Margarita; Ramirez, Gemma; Hernández García, José María; Aránega, Antonia; De-Teresa-Galván, Eduardo[et al.] (Wiley Online Library, 2011-04-25)
Preinfarction angina, a possible form of ischaemic preconditioning, improves the prognosis inpatients who experience a major ischaemic event; though the associated pathophysiology is not yet fully under-stood. The aim of ... -
LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance.
Moreno-Fernández, R.; Rosell-del-Valle, Cristina; Bacq, Alexandre; Zanoletti, Olivia; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Gavito, Ana L.; García-Fernández, María Inmaculada; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Sandi, Carmen; Pedraza-Benítez, María del Carmen[et al.] (Neuropharmacology, 2020-03-01)
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the ... -
Microglial and neurogenic alterations in hypothalamus due to acute stress
Infantes-López, M. Inmaculada; Nieto-Quero, Andrea; Zambrana-Infantes, Emma; Chaves-Peña, Patricia; Tabbai-Amal, Sara; Pedraza-Benítez, María del Carmen; Pérez-Martín, Margarita[et al.] (2021-07)
Microglial cells are an important glial population known to be involved in several biological processes such as stress response. These cells engage an activated state following a stress insult that may lead to nervous ... -
Mild juvenile stress increases resilience to the development of anxious behaviors and prevents neurogenic reduction after stress exposure in adulthood.
Chaves-Peña, Patricia; Infantes-López, M. Inmaculada; Nieto-Quero, Andrea; Zambrana-Infantes, Emma; Muñoz-Martín, José; Pérez-Martín, Margarita; Pedraza-Benítez, María del Carmen[et al.] (2023)
Stress, especially during sensitive periods of development, can induce neuroplastic changes in brain regions such as the hippocampus, which increases vulnerability to the negative effects of a second stressor during ... -
Propuesta de evaluación del Trabajo Fin de Grado de Biología basada en competencias
Altamirano-Jeschke, María; Rubio-Valverde, Lourdes; Muñoz-Gallego, Antonio Román; Figueirido-Castillo, Francisco Borja; Pérez-Martín, Margarita; Sánchez-Romero, Carolina; Trigo-Pérez, María del Mar; Blanco-López, Ángel[et al.] (2014-07-01)
La formación del profesorado para las tareas de evaluación y tutorización de los Trabajos Fin de Grado (TFG) constituye uno de los factores importantes a tener en cuenta para su exitosa implantación. Así, el objetivo de ...