Listar por autor "Pedraza-Benítez, Maria del Carmen"
Mostrando ítems 1-20 de 30
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Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test
Moreno-Fernández, Román D.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita
; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; García-Fernández, Maria Inmaculada; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2016-07-20)
Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ... -
The absence of LPA1 receptor results in lipidome dysregulation and Neuropeptide-Y underexpression
Tabbai, Sara; Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; Fernández, María; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2018-07-18)
LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signaling molecule. It has been shown that the LPA1 receptor is involved in ... -
Acute psychological stress: effects on hippocampal neurogenesis and the role of microglia
Nieto-Quero, Andrea; Chaves-Peña, Patricia; Infantes-López, M. Inmaculada; Zambrana-Infantes, Emma; Tabbai, Sara; Muñoz-Martin, José; Pérez-Martín, Margarita; Pedraza-Benítez, Maria del Carmen[et al.] (2022)
Among all the factors that can contribute to the onset of psychopathological disorders, stress is the main environmental factor. The hippocampus is one of the most sensitive regions to the harmful effects of stress, in ... -
Anxiety and mild microglial activation in the amygdala two weeks after NA-induced neuroinflammation
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Pedraza-Benítez, Maria del Carmen; Mateos-Grondona, Jesús; López-Ávalos, María Dolores; León-Rodríguez, Ana[et al.] (Wiley Periodicals, LLC, 2021-07)
A single injection of neuraminidase (NA) within the cerebral ventricles (ICV) triggers an acute neuroinflammation. Neurological complications or behavioral alterations have been associated to neuroinflammation. While some ... -
Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis.
Rosell-del-Valle, Cristina; Pedraza-Benítez, Maria del Carmen; Manuel, Iván; Moreno-Rodríguez, Marta; Rodríguez-Puertas, Rafael; Castilla-Ortega, María Estela; Carames-Tejedor, Jose Maria; Gómez-Conde, Ana Isabel; Zambrana-Infantes, Emma; Ortega-Pinazo, Jesús; Serrano-Castro, Pedro Jesus; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021-06-06)
Several studies have demonstrated that lysophosphatidic acid (LPA) acts through its LPA receptors in multiple biological and behavioral processes, including adult hippocampal neurogenesis, hippocampal-dependent memory, and ... -
Cognitive impairment in a murine model of experimental autoimmune encephalomyelitis with relapsing-remitting course
Rosell-del-Valle, Cristina; Sánchez-Morales, Cristina; Gómez-Conde, Ana Isabel; Hurtado-Guerrero, Isaac; Fernández-Fernández, Óscar; Pedraza-Benítez, Maria del Carmen; Santin-Nuñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (2015-09-18)
Multiple sclerosis (MS) is a neuroinflammatory disorder characterized by demyelination and progressive axonal loss that affects the central nervous system. In addition of physical disability and the neurodegenerative ... -
Dataset Orbitrap Raw-Data Stress Hippocampus(1h-24h)
Nieto-Quero, Andrea; Infantes-López, M. Inmaculada; Pedraza-Benítez, Maria del Carmen; Pérez-Martín, Margarita (Universidad de Málaga, 2023-03-30)
We have examined the effect of an acute stress in the proteomic profile of hippocampus. For this purpose, to extract information from proteomic profiles (1 and 24 hours post-acute stress) a Quadrupole-Orbitrap mass ... -
Dataset Orbitrap Raw-Data Stress Hypothalamus(1h-24h)
Infantes-López, M. Inmaculada; Nieto-Quero, Andrea; Pérez-Martín, Margarita; Pedraza-Benítez, Maria del Carmen (Universidad de Málaga, 2023-03-30)
We have examined the effect of an acute stress in the proteomic profile of hypothalamus. For this purpose, to extract information from proteomic profiles (1 and 24 hours post-acute stress) a Quadrupole-Orbitrap mass ... -
Determinación de las especies de LPA en hipocampo de ratón. Efecto de diferentes protocolos de estrés
(UMA Editorial, 2020)El LPA es un lípido bioactivo que está involucrado en la señalización intracelular a través de los seis receptores acoplados a proteínas G (LPA1-6). Entre estos receptores, LPA1 es un fuerte candidato para mediar los efectos ... -
Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models
Nieto-Quero, Andrea; Chaves-Peña, Patricia; Santin-Nuñez, Luis Javier; Pérez-Martín, Margarita; Pedraza-Benítez, Maria del Carmen (ELSEVIER, 2021-11)
Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain ... -
Efectos del estrés sobre comportamientos de tipo depresivo, la microglía y la neurogénesis hipocampal. Papel del sistema LPA endógeno
(UMA Editorial, 2022)El estrés constituye el principal factor ambiental en la etiología de los trastornos psicopatológicos, entre ellos la depresión. El hipocampo es una de las regiones más sensibles a los efectos nocivos del estrés, pudiendo ... -
Effects of chronic stress on hippocampal microglia and neurogenesis of mice under social defeat stress.
Muñoz-Martín, José; Infantes-López, M. Inmaculada; Chaves-Peña, Patricia; Nieto-Quero, Andrea; Zambrana-Infantes, Emma; Pedraza-Benítez, Maria del Carmen; Pérez-Martín, Margarita[et al.] (2022-07)
Introduction: Chronic stress is the main environmental factor in the aetiology of depression and it is known that this type of stress may cause alterations in brain regions such as the hippocampus. Nevertheless, changes ... -
Effects on the hippocampal microglia after acute treatment of a psychological stressor associated with depressive-like behaviours
Nieto-Quero, Andrea; Infantes-López, M. Inmaculada; Zambrana-Infantes, Emma; Chaves-Peña, Patricia; Tabbai-Amal, Sara; Pérez-Martín, Margarita; Pedraza-Benítez, Maria del Carmen[et al.] (2021-07)
Stressful life events may have a negative impact on mental health compromising people's well-being, so knowing the neurobiological changes that occur after psychosocial stressors can have an impact on overall health. ... -
Enhanced stress response in rats that suffered acute neuroinflammation induced by neuraminidase three months before
León-Rodríguez, Ana; Mateos-Grondona, Jesús; Fernández-Arjona, María del Mar; Pedraza-Benítez, Maria del Carmen; López-Ávalos, María Dolores (2022)
Microglial cells are protagonists in neuroinflammatory processes and their activation is a notorious feature of such events. In acute inflammation, microglial cells return to their basal surveillant state in few days. ... -
Estrés y depresión. El papel del receptor LPA1 para el ácido lisofosfatídico
(Uma Editorial, 2019-10)La depresión es un trastorno muy prevalente, cuya incidencia está en aumento y con consecuencias devastadoras en la salud de las personas. A pesar de ello, las bases neurobiológicas no son del todo conocidas. Esto podría ... -
Evaluación neuropsicológica del procesamiento emocional en el envejecimiento normal, deterioro cognitivo leve y enfermedad de Alzheimer
Cardenas-Ruiz, Jose (Servicio de Publicaciones y Divulgación Científica, 2016)
Evaluación neuropsicológica del reconocimiento de la identidad facial y de la expresión facial a través de una adaptación de la batería de exploración de emociones FAB -
LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance.
Moreno-Fernández, R.; Rosell-del-Valle, Cristina; Bacq, Alexandre; Zanoletti, Olivia; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Gavito, A.L.; García-Fernández, Maria Inmaculada; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Sandi, Carmen; Pedraza-Benítez, Maria del Carmen[et al.] (Neuropharmacology, 2020-03-01)
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the ... -
LPA1/3 receptor antagonist KI16425 as a novel treatment for the neurobehavioural effects of the ethanol
Ladrón de Guevara-Miranda, David; Sánchez-Marín, Laura; Alén, Francisco; Moreno-Fernández, Román D.; García-Fernández, Maria Inmaculada; Gil Rodríguez, Sara; Gavito, Ana; García-Marchena, Nuria; Pedraza-Benítez, Maria del Carmen; Pavón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Serrano, Antonia; Castilla-Ortega, María Estela[et al.] (2017-07-24)
Aims. The lysophosphatidic acid (LPA) is an ubiquitous lysophospholipid that acts through G-protein coupled receptors (LPA1-6), and it is involved in the modulation of emotional and motivational behaviors. Recent literature ... -
Microglial and neurogenic alterations in hypothalamus due to acute stress
Infantes-López, M. Inmaculada; Nieto-Quero, Andrea; Zambrana-Infantes, Emma; Chaves-Peña, Patricia; Tabbai-Amal, Sara; Pedraza-Benítez, Maria del Carmen; Pérez-Martín, Margarita[et al.] (2021-07)
Microglial cells are an important glial population known to be involved in several biological processes such as stress response. These cells engage an activated state following a stress insult that may lead to nervous ... -
Neuraminidase-induced neuroinflammation causes anxiety and microgliosis in the amygdala
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Pedraza-Benítez, Maria del Carmen; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (2021)
An intracerebroventricular (ICV) injection of neuraminidase (NA) within the lateral ventricles originates an acute event of neuroinflammation, which is solved to a great extent after two weeks. Recently, neurological ...