Listar por autor "Ruiz-Villalba, Adrián"
Mostrando ítems 1-15 de 15
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Characterization of epicardial-derived cardiac interstitial cells: differentiation and mobilization of heart fibroblast progenitors
The non-muscular cells that populate the space found between cardiomyocyte fibers are known as 'cardiac interstitial cells' (CICs). CICs are heterogeneous in nature and include different cardiac progenitor/stem cells, ... -
Epicardial development revisited: proepicardial heterogeneity.
(UMA Editorial, 2024)Las células epiteliales epicárdicas y las células mesenquimales derivadas de epicardio son fundamentales para el desarrollo del corazón embrionario. Su contribución a la formación del intersticio cardiaco, mediante la ... -
Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio-venous connections
Cano, Elena; Carmona-Mejías, Rita María
; Ruiz-Villalba, Adrián; Rojas, Anabel; Chau, You-Ying; Wagner, Kay-Dietrich; Wagner, Nicole; Hastie, Nicholas D.; Muñoz-Chápuli-Oriol, Ramón; Pérez-Pomares, José María[et al.] (Proceedings of the National Academy of Sciences (PNAS), 2016-01)
Recent reports suggest that mammalian embryonic coronary endothelium (CoE) originates from the sinus venosus and ventricular endocardium. However, the contribution of extracardiac cells to CoE is thought to be minor and ... -
Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice
(Oxford University Press, 2020)Aims: SCN5A mutations are associated with arrhythmia syndromes, including Brugada syndrome, long QT syndrome type 3 (LQT3), and cardiac conduction disease. Long QT syndrome type 3 patients display atrio-ventricular (AV) ... -
Hagfish and lamprey Hox genes reveal conservation of temporal colinearity in vertebrates
(Springer Nature, 2018)Hox genes exert fundamental roles for proper regional specification along the main rostro-caudal axis of animal embryos. They are generally expressed in restricted spatial domains according to their position in the cluster ... -
In vivo and In vitro cartilage differentiation from embryonic epicardial progenitor cells
Marín-Sedeño, Ernesto; Ruiz-Villalba, Adrián; Palmquist-Gomes, Paul; Sánchez Tévar, Ana María; Rico-Llanos, Gustavo Adolfo; Pérez-Pomares, José María; Guadix-Domínguez, Juan Antonio[et al.] (2022)
The presence of cartilage tissue in embryonic and adult hearts of various vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac ... -
Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells form myocardial infarction scar
Ruiz-Villalba, Adrián; Simon, Ana María; Pogontke, Cristina; Castillo, Maria I; Abizanda, Gloria; Pelacho, Beatriz; Sanchez-Dominguez, Rebeca; Segovia, Jose C; Prósper, Felipe; Pérez-Pomares, José María[et al.] (2015-05)
Background: Although efforts continue to find new therapies to regenerate infarcted heart tissue, knowledge of the cellular and molecular mechanisms involved remains poor. Objectives: This study sought to identify the ... -
Myocardial infarction ´through the window´: dual dynamics for cardiac fibroblasts activation
Ruiz-Villalba, Adrián; Hernández, Silvia C.; Ainciburu, Marina; Vilas-Zornoza, Amaia; Sudupe, Laura; Sarvide, Sarai; Planell, Nuria; Ripalda-Cemboráin, Purificación; Abizanda, Gloria; Pérez-Pomares, José María; Gómez-Cabrero, David; Prósper, Felipe[et al.] (2022)
Activated cardiac fibroblasts (CFs) are responsible for the healing of the heart tissue after a myocardial infarction (MI). Based on high throughput technologies, several groups have recently demonstrated their heterogeneity ... -
Reference genes for gene expression studies in the mouse heart
(Springer Nature, 2017)To be accurate, quantitative Polymerase Chain Reaction (qPCR) studies require a set of stable reference genes for normalization. This is especially critical in cardiac research because of the diversity of the clinical and ... -
Secretome of epicardial-derived cells: extracellular vesicles and Matrix
(UMA Editorial, 2022)El epicardio es un conjunto de células epiteliales de origen extracardiaco y se incorpora a la superficie del corazón hasta envolver el miocardio. Estas células sufren un proceso de transición epitelio-mesénquima (TEM) por ... -
Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction
(2020)Background: Cardiac fibroblasts (CFs) have a central role in the ventricular remodeling process associated with different types of fibrosis. Recent studies have shown that fibroblasts do not respond homogeneously to heart ... -
The expanding role of the epicardium and epicardial-derived cells in cardiac development and disease
Ruiz-Villalba, Adrián; Pérez-Pomares, José María (2012-10)
In this review, we aim at presenting and discussing the cellular and molecular mechanisms of embryonic epicardial development that may underlie the origin of congenital heart disease (CHD). -
Uncovering reparative cardiac fibroblasts activation following myocardial infarction.
López-Moreno, María; Cobos-Figueroa, Jorge; Cano-Rincón, Elena; Pogontke, Cristina; Chicano-Gálvez, Eduardo; Sancho, David; Ruiz-Villalba, Adrián; Guadix-Domínguez, Juan Antonio; Pérez-Pomares, José María; Ruiz-Villalba, Adrián[et al.] (Universidad de Málaga, 2025)
El infarto de miocardio (IM) es una de las principales causas de muerte, en parte debido a la fibrosis cardíaca resultante. Tras un IM, los fibroblastos cardíacos se activan y producen matriz extracelular (ECM), mientras ... -
Unravelling the mechanisms regulating embryonic epicardial cell proliferation.
Marín-Sedeño, Ernesto; Díaz del Moral, Sandra; Sánchez-Mata, Alicia; Díaz-Martínez, Luis; Lescroart, Fabienne; Ruiz-Villalba, Adrián; Pérez-Pomares, José María[et al.] (2023)
Epicardial development is a highly complex process that relies on the precise coordination of cell proliferation and differentiation. The epicardium originates from an extracardiac cluster of cells, the proepicardium, which ... -
Wnt signaling in the heart fields: Variations on a common theme
(2016)Wnt signaling plays an essential role in development and differentiation. Heart development is initiated with the induction of precardiac mesoderm requiring the tightly and spatially controlled regulation of canonical and ...