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Listar por autor "Enjuanes, Luis"
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Identification of the mechanisms causing reversion to virulence in an attenuated SARS-CoV for the design of a genetically stable vaccine
Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Nieto-Torres, Jose Luis; DeDiego, Marta L.; Castaño-Rodriguez, Carlos; Fernandez-Delgado, Raul; Perlman, Stanley; Enjuanes, Luis[et al.] (Public Library of Science, 2015)A SARS-CoV lacking the full-length E gene (SARS-CoV-∆E) was attenuated and an effective vaccine. Here, we show that this mutant virus regained fitness after serial passages in cell culture or in vivo, resulting in the ... -
Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival
DeDiego, Marta L.; Nieto-Torres, Jose Luis; Regla-Nava, Jose Angel; Jimenez-Guardeño, Jose Manuel; Fernandez-Delgado, Raul; Fett, Craig; Castaño-Rodriguez, Carlos; Perlman, Stanley; Enjuanes, Luis[et al.] (ASM Journals, 2014)Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a respiratory disease that has a 10% mortality rate. We previously showed that SARS-CoV lacking the E gene (SARS-CoV-ΔE) is attenuated ... -
Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis
Nieto-Torres, Jose Luis; DeDiego, Marta L.; Verdiá-Báguena, Carmina; Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Fernandez-Delgado, Raul; Castaño-Rodriguez, Carlos; Alcaraz, Antonio; Torres, Jaume; Aguilella, Vicente M; Enjuanes, Luis[et al.] (2014)Deletion of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) envelope (E) gene attenuates the virus. E gene encodes a small multifunctional protein that possesses ion channel (IC) activity, an important function ... -
Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis.
DeDiego, Marta L.; Nieto-Torres, José Luis; Jiménez-Guardeño, José Manuel; Regla-Nava, Jose Ángel; Álvarez, Enrique; Oliveros, Juan Carlos; Zhao, Jincun; Fett, Craig; Perlman, Stanley; Enjuanes, Luis[et al.] (PLOS, 2011)Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected ... -
The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis
Jimenez-Guardeño, Jose Manuel; Nieto-Torres, Jose Luis; DeDiego, Marta L.; Regla-Nava, Jose Angel; Fernandez-Delgado, Raul; Castaño-Rodriguez, Carlos; Enjuanes, Luis[et al.] (2014)A recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif (PBM), a domain involved in protein-protein ...