Listar por autor "Márquez-Gómez, Javier"
Mostrando ítems 1-20 de 29
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Antioxidant responses related to temozolomide resistance in glioblastoma
Campos-Sandoval, José Ángel
; Gómez-García, María C.; Santos-Jiménez, Juan de los; Mates-Sánchez, José Manuel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier[et al.] (Elsevier, 2021)
Glioblastoma remains one of the most challenging and devastating cancers, with only a very small proportion of patients achieving 5-year survival. The current standard of care consists of surgery, followed by radiation ... -
Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors.
Blanco-Calvo, Eduardo; Bilbao, Ainhoa; Luque-Rojas, María Jesús; Palomino, Ana; Bermúdez Silva, Francisco Javier; Suárez-Pérez, Juan; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo; Gutiérrez-Pérez, Antonia; Campos-Sandoval, José A.; Márquez-Gómez, Javier; Rodriguez-de-Fonseca, Fernando[et al.] (Springer, 2012)
Lysophosphatidic acid is a phospholipid mediator that modulates neurodevelopment and neurogenesis in the hippocampus through its actions on LPA1 receptors. Emerging evidences support LPA1 as a mediator of learning and ... -
Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.
Martín-Rufián, Mercedes; Nascimento-Gomes, Renata; Higuero, Ana; Crisma, Amanda R.; Campos-Sandoval, José A.; Gómez-García, María C.; Cardona, Carolina; Cheng, Tzuling; Lobo, Carolina; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Szeliga, Monika; Albrecht, Jan; Curi, Rui; Márquez-Gómez, Javier; Colquhoun, Alison; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (Springer Nature, 2014)
Mitochondrial glutaminase (GA) plays an essential role in cancer cell metabolism, contributing to biosynthesis, bioenergetics, and redox balance. Humans contain several GA isozymes encoded by the GLS and GLS2 genes, but ... -
Caracterización estructural y funcional de la isoenzima glutaminasa GLS2 y su implicación en cáncer
(UMA Editorial, 2022)Las isoenzimas de glutaminasa (GLS y GLS2) catalizan el primer paso de la ruta de la glutaminolisis (conversión de glutamina a glutamato e iones amonio) y desempeñan un papel clave en crecimiento y proliferación del cáncer. ... -
Changes in the nuclear proteomic profiling of human glioblastoma cells after glutaminase overexpression
Márquez-Gómez, Javier; Cardona Ramírez, Carolina; Alonso-Carrión, Francisco José; Lobo, Carolina; Campos-Sandoval, José Ángel; Martín Rufián, Mercedes[et al.] (2013)
Human glutaminase (GA) enzymes are the products of two genes, GLS and GLS2. GA isozymes play markedly different roles in tumour biology: GLS isoforms (KGA and GAC) are related to cell growth and proliferation, whereas GLS2 ... -
Cocaine modulates both glutaminase gene expression and glutaminase activity in the brain of cocaine-sensitized mice
Blanco-Calvo, Eduardo; Campos-Sandoval, José Ángel; Palomino, Ana; Luque-Rojas, María Jesús; Bilbao, Ainhoa; Suárez, Juan; Márquez-Gómez, Javier; Rodriguez-de-Fonseca, Fernando[et al.] (Springer, 2012)
Glutaminase is considered the main Glutamate (Glu) producing enzyme. Two isoforms, liver (LGA) and kidney (KGA) type glutaminases have been identified in neurons. The role of both enzymes in psychopharmacological responses ... -
Design and generation of a glutaminase GLS2 conditional knockout mice
Peñalver, Ana; Tosina, Marta; Martín-Rufián, Mercedes; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Segura-Checa, Juan Antonio; Mates-Sánchez, José Manuel; Ramírez, Miguel Ángel; Gutiérrez-Adán, Alfonso; Márquez-Gómez, Javier[et al.] (2014-10-04)
Mammalian glutaminase (GA; EC 3.5.1.2) is the main enzyme involved in brain generation of glutamate (Glu). This amino acid acts as an excitatory neurotransmitter within the CNS, and it is also implicated in behavioral ... -
Dysregulation of glutaminase and glutamine synthetase in cancer.
Mates-Sánchez, José Manuel; Campos-Sandoval, José Ángel; De los Santos-Jiménez, Juan; Márquez-Gómez, Javier (Elsevier, 2019)
Besides fast glucose catabolism, many types of cancers are characterized by elevated glutamine consumption. Medical oncology pursuits to block specific pathways, mainly glycolysis and glutaminolysis, in tumor cells to ... -
Expression of Gls and Gls2 glutaminase isoforms in astrocytes
Cardona, Carolina; Sánchez-Mejías, Elisabeth; Dávila-Cansino, José Carlos; Martín-Rufián, Mercedes; Campos-Sandoval, José Ángel; Vitorica Ferrández, Javier; Alonso-Carrión, Francisco José; Mates-Sánchez, José Manuel; Segura-Checa, Juan Antonio; Norenberg, Michael D.; Rama Rao, Kakulavarapu V.; Jayakumar, Arumugan R.; Gutiérrez-Pérez, Antonia; Márquez-Gómez, Javier[et al.] (Wiley, 2015-03)
The expression of glutaminase in glial cells has been a controversial issue and matter of debate for many years. Actually, glu-taminase is essentially considered as a neuronal marker in brain. Astrocytes are endowed with ... -
Expression of Gls and Gls2 glutaminase isoforms in astrocytes
Cardona, Carolina; Sánchez-Mejías, Elisabeth; Dávila-Cansino, José Carlos; Martín-Rufián, Mercedes; Campos-Sandoval, José Ángel; Vitorica Ferrández, Javier; Alonso-Carrión, Francisco José; Mates-Sánchez, José Manuel; Segura-Checa, Juan Antonio; Norenberg, Michael; Rama Rao, Kakulavarapu; Jayakumar, Arumugan; Gutiérrez-Pérez, Antonia; Márquez-Gómez, Javier[et al.] (Wiley, 2015)
The expression of glutaminase in glial cells has been a controversial issue and matter of debate for many years. Actually, glutaminase is essentially considered as a neuronal marker in brain. Astrocytes are endowed with ... -
Generación y caracterización de modelos murinos transgénicos para el análisis de glutaminasas cerebrales
(UMA Editorial, 2016)El estudio de modelos murinos transgénicos deficientes para un determinado gen (knockout, KO) es una de las principales herramientas que permite elucidar la función génica. Con el objetivo de modificar secuencias endógenas, ... -
GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells.
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; Mates-Sánchez, José Manuel (MDPI, 2024-06-20)
A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium. There are two types of GA isozymes, named ... -
Glutaminasa GLS2 en cerebro y cáncer: nuevas localizaciones celulares e identificación de proteínas interactivas mediante aproximaciones neuroquímicas y proteómicas
(Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)En este trabajo se resumen importantes nuevas funciones asociadas a la expresión de isoenzimas glutaminasa (GA; EC 3.5.1.2), tanto en cerebro como en células cancerosas, con especial énfasis en las isoenzimas Gls2. En ... -
Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA1 Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity
Peñalver Alonso, Ana; Campos-Sandoval, José Ángel; Blanco-Calvo, Eduardo; Cardona Ramírez, Carolina; Castilla, Laura; Martín-Rufián, Mercedes; Estivill-Torrús, Guillermo; Sánchez-Varo, Raquel María; Alonso-Carrión, Francisco José; Pérez-Hernández, Mercedes; Colado, María Isabel; Gutiérrez-Pérez, Antonia; Rodriguez-de-Fonseca, Fernando; Márquez-Gómez, Javier[et al.] (Frontiers, 2017-09-05)
Lysophosphatidic acid (LPA) is an extracellular lipid mediator that regulates nervous system development and functions acting through G protein-coupled receptors (GPCRs). Here we explore the crosstalk between LPA1 receptor ... -
Glutaminase isoenzymes in the metabolic 1 therapy of cancer
Mates-Sánchez, José Manuel; Campos-Sandoval, José Ángel; Márquez-Gómez, Javier (Elsevier, 2018-07)
Altered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine metabolism and their expression correlate with ... -
Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Márquez-Torres, Clara; Urbano-Polo, Nieves; Brøndegaard, David; Martín-Rufián, Mercedes; Lobo, Carolina; Peñalver Alonso, Ana; Gómez García, María del Carmen; Martín-Campos, Janet; Cardona Ramírez, Carolina; Castilla, Laura; Da-Costa-Souza, Felipe; Cheng, Tzuling; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Curi, Rui; Colquhoun, Alison; DeBerardinis, Ralph J; Márquez-Gómez, Javier; Mates-Sánchez, José Manuel[et al.] (BMC, 2021-02-20)
Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs) have been implicated ... -
Glutaminase-2 Expression Induces Metabolic Changes and Regulates Pyruvate Dehydrogenase Activity in Glioblastoma Cells
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Rosales, Tracy; Ko, Bookyung; Alonso, Francisco J.; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (MDPI, 2025-01-06)
Glutaminase controls the first step in glutaminolysis, impacting bioenergetics, biosynthesis and oxidative stress. Two isoenzymes exist in humans, GLS and GLS2. GLS is considered prooncogenic and overexpressed in many ... -
Glutaminases regulate glutathione and oxidative stress in cancer.
Mates-Sánchez, José Manuel; Campos-Sandoval, José Ángel; De los Santos-Jiménez, Juan; Márquez-Gómez, Javier (Springer Nature, 2020)
Targeted therapies against cancer have improved both survival and quality of life of patients. However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic mightiness. Resistant cells generate more ... -
Lysophosphatidic Acid and Glutamatergic Transmission.
Roza, Carolina; Campos-Sandoval, José Ángel; Gómez García, María del Carmen; Peñalver Alonso, Ana; Márquez-Gómez, Javier (Frontiers, 2019-05-28)
Signaling through bioactive lipids regulates nervous system development and functions. Lysophosphatidic acid (LPA), a membrane-derived lipid mediator particularly enriched in brain, is able to induce many responses in ... -
Mammalian Glutaminase Gls2 Gene Encodes Two Functional Alternative Transcripts by a Surrogate Promoter Usage Mechanism.
Martín-Rufián, Mercedes; Tosina, Marta; Campos-Sandoval, José Ángel; Manzanares, Elisa; Lobo, Carolina; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Mates-Sánchez, José Manuel; Márquez-Gómez, Javier[et al.] (PLOS, 2012-06-05)
Glutaminase is expressed in most mammalian tissues and cancer cells, but the regulation of its expression is poorly understood. An essential step to accomplish this goal is the characterization of its species- and cell-specific ...