Listar por autor "Lucena-González, María Isabel"
Mostrando ítems 1-20 de 42
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A revised electronic version of RUCAM for the diagnosis of DILI
Hayashi, Paul H.; Lucena-González, María Isabel
; Fontana, Robert J.; Bjornsson, Einar S.; Aithal, Guruprasad P.; Barnhart, Huiman; González-Jiménez, Andrés; Yang, Qinghong; Gu, Jiezhun; Andrade-Bellido, Raúl Jesús; Hoofnagle, Jay H.[et al.] (Wiley, 2022)
Background and Aims: Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug-Induced Liver Injury Network ... -
Análisis de las propiedades farmacológicas, los factores del huésped y su interacción en el desarrollo de hepatotoxicidad asociada a fármacos
(UMA Editorial, 2017)INTRODUCTION Drug-induced liver injury is an important concern in public health. In addition, it is one of the most common adverse events that cause lack of drug approval, drug withdrawals, and post-marketing regulatory ... -
Características diferenciales de la expresión del daño hepático y gravedad en la hepatotoxicidad por hierbas y suplementos dietéticos: estudio de los Registros Español y Latinoamericano de Hepatotoxicidad
(UMA Editorial, 2015)El daño hepático asociado a hierbas y suplementos dietéticos (HDS) es un problema creciente de salud pública debido a su uso extendido, al laxo y heterogéneo marco de regulación y al riesgo que representa para la salud. ... -
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Villanueva-Paz, Marina; Aukštikalnė, Lauryna; Stephens, Camilla; Robles-Díaz, María Mercedes; Pinazo-Bandera, José M.; García-Cortés, Miren; Conde, Isabel; Soriano, German; Bessone, Fernando; Hernandez, Nelia; Nunes, Vinicius; Parana, Raymundo; Lucena-González, María Isabel; Andrade, Raúl J.; Alvarez-Alvarez, Ismael; Niu, Hao[et al.] (Springer Nature, 2023-12-05)
Idiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRESS) is poorly characterized among patients of Western countries. We aimed to comprehensively assess ... -
Characterizing Highly Cited Papers in Mass Cytometry through H-Classics
Di Zeo-Sánchez, Daniel Enrique; Sánchez-Núñez, Pablo; Stephens, Camilla; Lucena-González, María Isabel (IOAP-MPDI, 2021-02-02)
Mass cytometry (CyTOF) is a relatively novel technique for the multiparametric analysis of single-cell features with an increasing central role in cell biology, immunology, pharmacology, and biomedicine. This technique ... -
Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old
Weersink, Rianne A.; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Robles-Díaz, María Mercedes; Ortega-Alonso, Aida; García-Cortés, Miren; Bonilla, Elvira; Niu, Hao; Soriano, German; Jiménez-Pérez, Miguel; Hallal, Hacibe; Blanco, Sonia; Kaplowitz, Neil; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2020-11-11)
Old patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. We sought for the distinctive characteristics of DILI in older patients across age groups. A total of ... -
Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries
García-Cortés, Miren; Ortega-Alonso, Aida; Matilla-Cabello, Gonzalo; Medina-Cáliz, Inmaculada; Castiella, Agustin; Conde, Isabel; Bonilla-Toyos, Elvira; Pinazo-Bandera, José M.; Hernandez, Nelia; Tagle, Martin; Nunes, Vinicius; Parana, Raymundo; Bessone, Fernando; Kaplowitz, Neil; Lucena-González, María Isabel; Alvarez-Alvarez, Ismael; Robles-Díaz, María Mercedes; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2023)
Background & aims: Idiosyncratic drug-induced liver injury (DILI) with autoimmune features is a liver condition with laboratory and histological characteristics similar to those of idiopathic autoimmune hepatitis (AIH), ... -
Compatibilidad y estabilidad físico-química de mezclas de medicamentos en infusores para vía subcutánea suceptibles de ser utilizadas en pacientes de cuidados paliativos en Andalucía
(UMA Editorial, 2020-09-04)La utilización de la vía subcutánea para la administración de medicamentos en Cuidados Paliativos es una vía muy interesante cuando la vía oral no está disponible. El empleo de infusores para la perfusión continua permite ... -
Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry
Stephens, Camilla; Robles-Díaz, María Mercedes; Medina-Cáliz, Inmaculada; García-Cortés, Miren; Ortega-Alonso, Aida; Sanabria-Cabrera, Judith Adriana; González-Jiménez, Andrés; Alvarez-Alvarez, Ismael; Slim, Mahmoud; Jiménez-Pérez, Miguel; González-Grande, Rocío; Fernández, M. Carmen; Casado, Marta; Soriano, German; Roman, Eva; Hallal, Hacibe; Romero-Gomez, Manuel; Castiella, Agustin; Conde, Isabel; Prieto, Martin; Moreno-Planas, José María; Giraldez, Alvaro; Moreno-Sanfiel, J Miguel; Kaplowitz, Neil; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Elsevier, 2021-02-01)
Background & aims: Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into ... -
Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions
Villanueva-Paz, Marina; Niu, Hao; Segovia-Zafra, Antonio; Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Alvarez-Alvarez, Ismael; Sanabria-Cabrera, Judith Adriana[et al.] (MDPI, 2021-11-15)
Drug-induced liver injury (DILI) encompasses the unexpected damage that drugs can cause to the liver. DILI may develop in the context of an immunoallergic syndrome with cutaneous manifes- tations, which are sometimes severe ... -
Drug properties and host factors contribute to biochemical presentation of drug-induced liver injury: a prediction model from a machine learning approach
González-Jiménez, Andrés; Suzuki, Ayako; Chen, Minjun; Ashby, Kristin; Alvarez-Alvarez, Ismael; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Springer, 2021-03-05)
Drug-induced liver injury (DILI) presentation varies biochemically and histologically. Certain drugs present quite consistent injury patterns, i.e., DILI signatures. In contrast, others are manifested as broader types of ... -
Evaluación de causalidad en hepatotoxicidad
García-Cortés, Miren (Universidad de Málaga, Servicio de Publicaciones, 2006)
La hepatotoxicidad es un problema de salud pública infranotificado debido a la ausencia de marcadores diagnósticos específicos. En las últimas décadas se han venido desarrollando distintos métodos diagnósticos en ... -
Evaluación de las necesidades terapeúticas en personas con trastornos de la diferenciaón sexual.
(UMA Editorial, 2017-07-07)La palabra intersexualidad es aplicada generalmente a la situación clínica de un recién nacido con genitales externos lo suficientemente ambigüos para que la asignación del sexo sea incierta. Actualmente, se ha sustituido ... -
Evaluation of diagnostic and prognostic candidate biomarkers in drug-induced liver injury vs. other forms of acute liver damage
Cueto-Sánchez, Alejandro; Niu, Hao; Alvarez-Alvarez, Ismael; López-Longarela, Bárbara; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; García-Cortés, Miren; Pinazo-Bandera, José M.; Sanabria-Cabrera, Judith Adriana; Díaz-Monchón, Juan José; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Stephens, Camilla; Robles-Díaz, María Mercedes[et al.] (Wiley, 2023)
Aims Detection and characterization of idiosyncratic drug-induced liver injury (DILI) currently rely on standard liver tests, which are suboptimal in terms of specificity, sensitivity and prognosis. Therefore, DILI diagnosis ... -
Genetic polymorphisms of CYP2C9 and CYP2C19 are not related to drug-induced idiosyncratic liver injury (DILI)
Pachkoria, K.; Lucena-González, María Isabel; Ruiz-Cabello, Francisco; Crespo, Esperanza; Cabello-Porras, María Rosario; Andrade-Bellido, Raúl Jesús[et al.] (2007-01-29)
Background and purpose: The general view on the pathogenesis of drug-induced idiosyncratic liver injury (DILI) is that parent compounds are rendered hepatotoxic by metabolism, mainly by cytochrome (CYP) 450, although other ... -
Hepatic safety of atypical antipsychotics: current evidence and future directions
Slim, Mahmoud; Medina-Cáliz, Inmaculada; González-Jiménez, Andrés; Cabello-Porras, María Rosario; Mayoral Cleries, Fermín; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Springer, ADIS INT LTD, 2016-10)
The newer atypical antipsychotic agents (AAPs) represent an attractive therapeutic option for a wide range of psychotic disorders, including schizophrenia and bipolar mania, because of the reduced risk of disabling ... -
Herbal and dietary supplement-induced liver injuries in the spanish DILI registry
Medina-Cáliz, Inmaculada; García-Cortés, Miren; González-Jiménez, Andrés; Cabello-Porras, María Rosario; Robles-Díaz, María Mercedes; Sanabria-Cabrera, Judith Adriana; Sanjuan-Jimenez, Rocio; Ortega-Alonso, Aida; García-Muñoz, Beatriz; Moreno, Inmaculada; Jiménez-Pérez, Miguel; Fernández, M. Carmen; Ginés, Pere; Prieto, Martin; Conde, Isabel; Hallal, Hacibe; Soriano, German; Roman, Eva; Castiella, Agustin; Blanco-Reina, Encarnación; Montes, Maria R; Quiros-Cano, Marta; Martín-Reyes, Flores; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Elsevier, 2018-01)
There have been increasing reports of liver injury associated with use of herbal and dietary supplements.We collected and analyzed data on demographic and clinical features, along with biochemical parameters, of 32 patients ... -
Herbal and dietary supplements-induced liver injury in Latin America: Experience from the LATINDILI Network
Bessone, Fernando; García-Cortés, Miren; Medina-Cáliz, Inmaculada; Hernandez, Nelia; Parana, Raymundo; Mendizabal, Manuel; Schinoni, María I.; Ridruejo, Ezequiel; Nunes, Vinicius; Peralta, Mirta; Santos, Genario; Anders, Margarita; Chiodi, Daniela; Tagle, Martin; Montes, Pedro; Carrera, Enrique; Arrese, Marco; Lizarzabal, M. Isabel; Alvarez-Alvarez, Ismael; Caballano-Infantes, Estefanía; Niu, Hao; Pinazo, Jose; Cabello-Porras, María Rosario; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Elsevier, 2022)
Background: Herbal and dietary supplements (HDS) consumption, a growing cause of hepatotoxicity, is a common practice among Latin-American populations. Objectives: To evaluate clinical, laboratory features and outcome ... -
Histological and serological features of acute liver injury after SARS-CoV-2 vaccination
Codoni, Greta; Kirchner, Theresa; Engel, Bastian; Villamil, Alejandra Maria; Efe, Cumali; Friedrich Stättermayer, Albert; Weltzsch, Jan Philipp; Sebode, Marcial; Bernsmeier, Christine; Lleo, Ana; Gevers, Tom JG.; Kupčinskas, Limas; Castiella, Agustin; Pinazo, Jose; De Martin, Eleonora; Bobis, Ingrid; Damgaard Sandahl, Thomas; Pedica, Federica; Invernizzi, Federica; Del Poggio, Paolo; Bruns, Tony; Kolev, Mirjam; Semmo, Nasser; Bessone, Fernando; Giguet, Baptiste; Poggi, Guido; Ueno, Masayuki; Jang, Helena; Elpek, Gülsüm Özlem; Karadağ Soylu, Neşe; Cerny, Andreas; Wedemeyer, Heiner; Vergani, Diego; Mieli-Vergani, Giorgina; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Zen, Yoh; Taubert, Richard; Terziroli Beretta-Piccoli, Benedetta[et al.] (Elsevier, 2022)
Liver injury with autoimmune features after vaccination against Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2) is increasingly reported. We investigated a large international cohort of patients with acute ... -
Incidence and prevalence of acute hepatitis E virus infection in patients with suspected Drug-Induced Liver Injury in the Spanish DILI Registry
Sanabria-Cabrera, Judith Adriana; Sanjuan-Jimenez, Rocio; Clavijo-Frutos, Encarnación; Medina-Cáliz, Inmaculada; González-Jiménez, Andrés; García-Cortés, Miren; Ortega-Alonso, Aida; Jiménez-Pérez, Miguel; González-Grande, Rocío; Stephens, Camilla; Robles-Díaz, María Mercedes; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (2020)
Background and Aims: Drug-induced liver injury (DILI) presents with a wide phenotypic spectrum requiring an extensive differential diagnosis. Hepatitis E virus (HEV) is not systematically ruled out during acute hepatitis ...