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Listar por autor "Perkins, James Richard"
Mostrando ítems 1-6 de 6
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CXCL5 mediates UVB irradiation-induced pain.
Dawes, John M; Calvo, Margarita; Perkins, James Richard; Paterson, Kathryn J; Kiesewetter, Hannes; Hobbs, Carl; Kaan, Timothy K.Y.; Orengo, Christine A.; Bennett, David LH; McMahon, Stephen B[et al.] (AAAS, 2011-07-06)Many persistent pain states (pain lasting for hours, days, or longer) are poorly treated because of the limitations of existing therapies. Analgesics such as nonsteroidal anti-inflammatory drugs and opioids often provide ... -
Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis
Lees, Jonathan; Yeats, Corin; Perkins, James Richard; Sillitoe, Ian; Rentzsch, Robert; Dessailly, Benoit H; Orengo, Christine A.[et al.] (Oxford University Press, 2012-01)Gene3D http://gene3d.biochem.ucl.ac.uk is a comprehensive database of protein domain assignments for sequences from the major sequence databases. Domains are directly mapped from structures in the CATH database or predicted ... -
PainNetworks: A web-based resource for the visualisation of pain related genes in the context of their network associations.
Perkins, James Richard; Lees, Jonathan; Antunes-Martins, Ana; Diboun, Ilhem; Mcmahon, Stephen B.; Bennett, David L. H.; Orengo, Christine A.[et al.] (IASP/Wolters Kluwer, 2013-08-11)We now know of hundreds of genes that have some association with pain. Several genes have been shown to alter pain sensitivity in humans, and can be found in the OMIM database. The Pain Gene Database gives details of genes ... -
ReadqPCR and NormqPCR: R packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (Cq) data
Perkins, James Richard; Dawes, John M; McMahon, Steve B; Bennett, David LH; Orengo, Christine A.; Kohl, Matthias[et al.] (BMC, 2012-07)Background: Measuring gene transcription using real-time reverse transcription polymerase chain reaction (RT-qPCR) technology is a mainstay of molecular biology. Technologies now exist to measure the abundance of many ... -
Transient protein-protein interactions: structural, functional, and network properties
Perkins, James Richard; Diboun, Ilhem; Dessailly, Benoit H; Lees, Jonathan G; Orengo, Christine A. (Elsevier, 2010-10-13)Transient interactions, which involve protein interactions that are formed and broken easily, are important in many aspects of cellular function. Here we describe structural and functional properties of transient interactions ... -
Unravelling adverse reactions to NSAIDs using systems biology.
Perkins, James Richard; Sanak, Marek; Canto, Gabriela; Blanca, Miguel; Cornejo-Garcia, Jose Antonio (Cell Press, 2015-01-08)Unpredictable adverse drug reactions are non-dose-related reactions that appear only in susceptible individuals. Their biological basis remains a puzzle. Here we introduce the reader to systems biology using adverse drug ...