Listar por autor "García-González, Pablo"
Mostrando ítems 1-2 de 2
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A Functional Pipeline of Genome-Wide Association Data Leads to Midostaurin as a Repurposed Drug for Alzheimer’s Disease
Esteban-Martos, Alvaro; Brokate-Llanos, Ana María; Real-Navarrete, Luis Miguel
; Melgar-Locatelli, Sonia; De Rojas, Itziar; Castro-Zavala, Adriana; Bravo-Romero, María José; Mañas-Padilla, María del Carmen; García-González, Pablo; Ruiz-Galdón, Maximiliano; Pacheco-Sánchez, Beatriz; Polvillo, Rocío; Rodriguez-de-Fonseca, Fernando; González, Irene; Castilla-Ortega, María Estela; Muñoz-Gómez, Manuel; Rivera, Patricia; Reyes-Engel, Armando; Ruiz, Agustín; Royo-Sánchez-Palencia, José Luis[et al.] (MDPI, 2023)
Genome-wide association studies (GWAS) constitute a powerful tool to identify the different biochemical pathways associated with disease. This knowledge can be used to prioritize drugs targeting these routes, paving the ... -
Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer’s Disease Aetiopathogenesis in Men
García-González, Pablo; Rojas, Itziar de; Moreno-Grau, Sonia; Montrreal, Laura; Puerta, Raquel; Alarcón-Martín, Emilio; Quintela, Inés; Orellana, Adela; Andrade, Victor; Martino Adami, Pamela V.; Heilmann-Heimbach, Stefanie; Gómez-Garre, Pilar; Periñán, María Teresa; Alvarez, Ignacio; Díez-Fairen, Mónica; Nuñez Llaves, Raul; Olivé Roig, Claudia; García-Ribas, Guillermo; Menéndez-González, Manuel; Martínez, Carmen; Aguilar, Miquel; Buongiorno, Mariateresa; Franco-Macías, Emilio; Saez, Maria Eugenia; Cano, Amanda; Bullido Gómez-Heras, Maria Jesús; Real-Navarrete, Luis Miguel; Rodríguez-Rodríguez, Eloy; Royo-Sánchez-Palencia, José Luis; Álvarez, Victoria; Pastor, Pau; Piñol-Ripoll, Gerard; Mir, Pablo; Calero Lara, Miguel; Medina Padilla, Miguel; Sánchez-Juan, Pascual; Carracedo Álvarez, Ángel María; Valero, Sergi; Hernández, Isabel; Tàrraga, Lluis; Ramirez, Alfredo; Boada, Mercé; Ruiz Laza, Agustín[et al.] (IOAP-MDPI, 2023-01-04)
Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY ...