Listar por autor "Caballero, Cristina"
Mostrando ítems 1-4 de 4
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Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model.
Jiménez, Sebastián; Torres, Manuel; Vizuete, Marisa; Sánchez-Varo, Raquel María
; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Carmona-Cuenca, Irene; Caballero, Cristina; Ruano, Diego; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Elsevier, 2011-05)
Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. We have ... -
Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease.
Ramos, Blanca; Baglietto-Vargas, David; del Rio, Juan Carlos; Moreno-González, Inés; Santa-Maria, Consuelo; Jiménez, Sebastián; Caballero, Cristina; López-Téllez, Juan Félix; Khan, Zafar U.; Ruano, Diego; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Elsevier, 2006-11)
At advanced stages, Alzheimer's disease (AD) is characterized by an extensive neuronal loss. However, the early neurodegenerative deficiencies have not been yet identified. Here we report an extensive, selective and early ... -
Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer’s Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic.
Jiménez, Sebastián; Baglietto-Vargas, David; Caballero, Cristina; Moreno-González, Inés; Torres, Manuel; Sánchez-Varo, Raquel María; Ruano, Diego; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Society for Neuroscience, 2008)
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs neurodegeneration) has not yet been resolved. Here, we show the existence of an age-dependent phenotypic ... -
Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice.
Caballero, Cristina; Jiménez, Sebastián; Moreno-González, Inés; Baglietto-Vargas, David; Sánchez-Varo, Raquel María; Gavilán, M. Paz; Ramos, Blanca; Del Río, Juan Carlos; Vizuete, María Luisa; Gutiérrez-Pérez, Antonia; Ruano, Diego; Vitorica Ferrández, Javier[et al.] (Wiley, 2007-01-22)
La detección de las primeras modificaciones fenotípicas de los modelos de la enfermedad de Alzheimer (EA) es fundamental para comprender la progresión e identificar dianas farmacológicas de esta patología. Sin embargo, se ...