Listar por autor "López-Gómez, Carlos"
Mostrando ítems 1-10 de 10
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Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiency.
(Wiley, 2017)Objective—Thymidine kinase 2 (TK2), a critical enzyme in the mitochondrial pyrimidine salvage pathway, is essential for mitochondrial DNA (mtDNA) maintenance. Mutations in the nuclear gene TK2 cause TK2 deficiency, which ... -
Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients
García-León, Juan Antonio
; Pinto-Medel, Mª Jesús; García-Trujillo, Lucía; López-Gómez, Carlos; Oliver-Martos, Begoña; Prat-Arrojo, Isidro; Marín-Bañasco, Carmen; Suardíaz-García, Margarita; Maldonado-Sánchez, Rafael; Fernández Fernández, Óscar; Leyva-Fernández, Laura[et al.] (Elsevier, 2011)
Killer cell immunoglobulin-like receptors (KIRs) are regulators of cytolytic activity of natural killer and certain T cells through interactions with human leukocyte antigen (HLA) class I ligands. KIRs have been shown to ... -
Killer-cell immunoglobulin-like receptor expression on lymphocyte subsets in multiple sclerosis patients treated with interferon-β: evaluation as biomarkers for clinical response
García-León, Juan Antonio; López-Gómez, Carlos; Orpez-Zafra, Teresa; Reyes-Garrido, Virginia; Marín Bañasco, Carmen; Oliver-Martos, Begoña; Fernández-Fernández, Óscar; Leyva-Fernández, Laura[et al.] (Springer Link, 2014)
Background: Both the adaptative and the innate immune systems interplay in multiple sclerosis (MS) pathogeny. Killer-cell immunoglobulin-like receptors (KIRs) are key regulators of the immune response, with activating and ... -
Membrane vesicles of toxigenic Clostridioides difficile affect the metabolism of liver hepG2 cells
Caballano-Infantes, Estefanía; Ho-Plágaro, Ailec; López-Gómez, Carlos; Martín-Reyes, Flores; Rodríguez-Pacheco, Francisca; Taminiau, Bernard; Daube, Georges; Garrido Sánchez, Lourdes; Alcaín-Martínez, Guillermo; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren; Lucena-González, María Isabel; García Fuentes, Eduardo; Rodriguez-Diaz, Cristina[et al.] (MDPI, 2023-03-27)
Clostridioides difficile infection (CDI) appears to be associated with different liver diseases. C. difficile secretes membrane vesicles (MVs), which may be involved in the development of nonalcoholic fatty liver disease ... -
Mitochondrial Stress Links Environmental Triggers with Pro-Inflammatory Signaling in Crohn's Disease
(MDPI, 2023)Inflammatory Bowel Diseases (IBD) are a group of chronic, inflammatory disorders of the gut. The incidence and activity of IBD are determined by both genetic and environmental factors. Among these factors, polymorphisms ... -
Modelo de célula.
(2024)Es un modelo de célula en 3D con el que poder explica cómo la compartimentación celular permite una especialización bioquímica de los diversos orgánulos que la constituyen y relacionarlos con su función celular. Este modelo ... -
Modelo mitocondria en 3D.
(2022)Es un modelo de mitocondria en 3D con el que poder explicar los procesos celulares, moleculares y bioquímicos en los que se encuentra implicado este orgánulo, de vital importancia para el correcto funcionamiento de las ... -
Neutralizing antibodies against IFN beta in patients with multiple sclerosis: a comparative study of two cytopathic effect tests (CPE) for their detection
Oliver-Martos, Begoña; Orpez, Teresa; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; López-Gómez, Carlos; Marín, Carmen; Luque, Gloria; Fernández Fernández, Óscar[et al.] (Elsevier, 2009)
The purpose of this study is to monitor the development of anti-natalizumab antibodies to evaluate their first appearance in multiple sclerosis patients, since their presence has been associated with a reduction in the ... -
Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction
Segovia-Zafra, Antonio; Di Zeo-Sánchez, Daniel Enrique; López-Gómez, Carlos; Pérez-Valdés, Zeus; García-Fuentes, Eduardo; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Villanueva-Paz, Marina[et al.] (Elsevier, 2021-12)
Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that pre- scription and non-prescription drugs, herbal and dietary supplements can cause to the liver. iDILI remains a major public health ... -
TRAIL and TRAIL receptors splice variants during long-term interferon β treatment of patients with multiple sclerosis: evaluation as biomarkers for therapeutic response
López-Gómez, Carlos; Oliver-Martos, Begoña; Pinto-Medel, María Jesús; Suardíaz García, Margarita; Reyes-Garrido, Virginia; Urbaneja, Patricia; Fernández-Fernández, Óscar; Leyva-Fernández, Laura[et al.] (BMJ Journals, 2016)
Objective We aimed to assess the effects of interferon β (IFNβ) treatment on the expression of the splice variants of the Tumour necrosis factor-Related Apoptosis Inducing Ligand (TRAIL) and its receptors in different cell ...