Listar por autor "Niu, Hao"
Mostrando ítems 1-19 de 19
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An individual patient data meta-analysis to determine cut-offs for and confounders of NAFLD-fibrosis staging with magnetic resonance elastography.
(Elsevier, 2023)We conducted an individual patient data meta-analysis to establish stiffness cut-off values for magnetic resonance elastography (MRE) in staging liver fibrosis and to assess potential confounding factors. A systematic ... -
Artificial Intelligence: an emerging tool for studying drug-induced liver injury.
(Wiley, 2025-02-21)Drug-induced liver injury (DILI) is a complex and potentially severe adverse reaction to drugs, herbal products or dietary supplements. DILI can mimic other liver diseases clinical presentation, and currently lacks specific ... -
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Medina-Cáliz, Inmaculada
; Sanabria-Cabrera, Judith Adriana; Villanueva-Paz, Marina; Aukštikalnė, Lauryna; Stephens, Camilla; Robles-Díaz, María Mercedes; Pinazo-Bandera, José M.; García-Cortés, Miren; Conde, Isabel; Soriano, German; Bessone, Fernando; Hernandez, Nelia; Nunes, Vinicius; Parana, Raymundo; Lucena-González, María Isabel; Andrade, Raúl J.; Alvarez-Alvarez, Ismael; Niu, Hao[et al.] (Springer Nature, 2023-12-05)
Idiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRESS) is poorly characterized among patients of Western countries. We aimed to comprehensively assess ... -
Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old
Weersink, Rianne A.; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Robles-Díaz, María Mercedes; Ortega-Alonso, Aida; García-Cortés, Miren; Bonilla, Elvira; Niu, Hao; Soriano, German; Jiménez-Pérez, Miguel; Hallal, Hacibe; Blanco, Sonia; Kaplowitz, Neil; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2020-11-11)
Old patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. We sought for the distinctive characteristics of DILI in older patients across age groups. A total of ... -
Control compounds for preclinical drug-induced liver injury assessment: Consensus-driven systematic review by the ProEuroDILI network
(Elsevier, 2024)Background & Aims Idiosyncratic drug-induced liver injury (DILI) is a complex and unpredictable event caused by drugs, and herbal or dietary supplements. Early identification of human hepatotoxicity at preclinical stages ... -
Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions
Villanueva-Paz, Marina; Niu, Hao; Segovia-Zafra, Antonio; Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Alvarez-Alvarez, Ismael; Sanabria-Cabrera, Judith Adriana[et al.] (MDPI, 2021-11-15)
Drug-induced liver injury (DILI) encompasses the unexpected damage that drugs can cause to the liver. DILI may develop in the context of an immunoallergic syndrome with cutaneous manifes- tations, which are sometimes severe ... -
Drug-Induced Liver Injury in Latin America: 10-year experience of the Latin American DILI (LATINDILI) Network
Bessone, Fernando; Hernandez, Nelia; Medina-Caliz, Inmaculada; García-Cortés, Miren; Schinoni, María I.; Mendizabal, Manuel; Chiodi, Daniela; Nunes, Vinicius; Ridruejo, Ezequiel; Pazos, Ximena; Santos, Genario; Fassio, Eduardo; Parana, Raymundo; Reggiardo, Virginia; Tanno, Hugo; Sanchez, Adriana; Tanno, Federico; Montes, Pedro; Tagle, Martin; Arrese, Marco; Brahm, Javier; Girala, Marcos; Lizarzabal, M. Isabel; Carrera, Enrique; Zerega, Alina; Bianchi, Carla; Reyes, Laura; Arnedillo, Daina; Cordone, Antonella; Gualano, Gisela; Jaureguizahar, Fernanda; Rifrani, Gabriel; Robles‑Diaz, Mercedes; Ortega-Alonso, Aida; Pinazo-Bandera, Jose M.; Stephens, Camilla; Sanabria-Cabrera, Judith; Bonilla-Toyos, Elvira; Niu, Hao; Alvarez-Alvarez, Ismael; Lucena, M. Isabel; Andrade, Raúl J.[et al.] (Elsevier, 2024-07)
Background and aims: Latin America is a region of great interest for studying the clinical presentation of idiosyncratic drug-induced liver injury (DILI). A comprehensive analysis of patients enrolled into the LATINDILI ... -
Evaluation of diagnostic and prognostic candidate biomarkers in drug-induced liver injury vs. other forms of acute liver damage
Cueto-Sánchez, Alejandro; Niu, Hao; Alvarez-Alvarez, Ismael; López-Longarela, Bárbara; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; García-Cortés, Miren; Pinazo-Bandera, José M.; Sanabria-Cabrera, Judith Adriana; Díaz-Monchón, Juan José; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Stephens, Camilla; Robles-Díaz, María Mercedes[et al.] (Wiley, 2023)
Aims Detection and characterization of idiosyncratic drug-induced liver injury (DILI) currently rely on standard liver tests, which are suboptimal in terms of specificity, sensitivity and prognosis. Therefore, DILI diagnosis ... -
Herbal and dietary supplements-induced liver injury in Latin America: Experience from the LATINDILI Network
Bessone, Fernando; García-Cortés, Miren; Medina-Cáliz, Inmaculada; Hernandez, Nelia; Parana, Raymundo; Mendizabal, Manuel; Schinoni, María I.; Ridruejo, Ezequiel; Nunes, Vinicius; Peralta, Mirta; Santos, Genario; Anders, Margarita; Chiodi, Daniela; Tagle, Martin; Montes, Pedro; Carrera, Enrique; Arrese, Marco; Lizarzabal, M. Isabel; Alvarez-Alvarez, Ismael; Caballano-Infantes, Estefanía; Niu, Hao; Pinazo, Jose; Cabello-Porras, María Rosario; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Elsevier, 2022)
Background: Herbal and dietary supplements (HDS) consumption, a growing cause of hepatotoxicity, is a common practice among Latin-American populations. Objectives: To evaluate clinical, laboratory features and outcome ... -
Lymphocyte Profile and Immune Checkpoint Expression in Drug-Induced Liver Injury: An Immunophenotyping Study
Cueto-Sánchez, Alejandro; Niu, Hao; Del Campo-Herrera, Enrique; Robles-Díaz, María Mercedes; Sanabria-Cabrera, Judith Adriana; Ortega-Alonso, Aida; García-Cortés, Miren; González-Grande, Rocío; Jiménez-Pérez, Miguel; Ruiz-Cabello, Francisco; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Wiley, 2021-09-20)
The identification of specific HLA risk alleles in drug-induced liver injury (DILI) points toward an important role of the adaptive immune system in DILI development. In this study, we aimed to corroborate the role of an ... -
N-acetylcysteine for the management of non-acetaminophen drug-induced liver injury in adults: a systematic review.
Sanabria-Cabrera, Judith Adriana; Tabbai-Amal, Sara; Niu, Hao; Alvarez-Alvarez, Ismael; Licata, Anna; Bjornsson, Einar S.; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Frontiers, 2022)
Introduction: Idiosyncratic drug-induced liver injury (DILI) is a rare adverse reaction to drugs and other xenobiotics. DILI has different grades of severity and may lead to acute liver failure (ALF), for which there is ... -
Nitrofurantoin‑induced liver injury: long‑term follow‑up in two prospective DILI registries
Bessone, Fernando; Ferrari, Antonella; Hernandez, Nelia; Mendizabal, Manuel; Zerega, Alina; Tanno, Federico; Reggiardo, Maria Virginia; Vorobioff, Julio; Tanno, Hugo; Arrese, Marco; Nunes, Vinicius; Tagle, Martin; Medina-Cáliz, Inmaculada; Robles‑Diaz, Mercedes; Niu, Hao; Alvarez-Alvarez, Ismael; Stephens, Camilla; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Springer Nature, 2022-11-22)
Nitrofurantoin is a synthetic antibiotic that is recommended as first-choice treatment for uncomplicated urinary tract infections. The prescription of this drug has increased dramatically, especially in Latin American ... -
Potential benefit and lack of serious risk from corticosteroids in drug-induced liver injury: an international, multicentre, propensity score-matched analysis
Niu, Hao; Ma, Jiayi; Medina-Cáliz, Inmaculada; Robles-Díaz, María Mercedes; Bonilla-Toyos, Elvira; Ghabril, Marwan; Lucena-González, María Isabel; Alvarez-Alvarez, Ismael; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2022-12-22)
Background: The use of corticosteroids to treat patients with idiosyncratic drug-induced liver injury (DILI) relies on empirical clinical decisions. Aim: To investigate the relationship between corticosteroids and ... -
Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials
Niu, Hao; Sanabria-Cabrera, Judith Adriana; Alvarez-Alvarez, Ismael; Robles-Díaz, María Mercedes; Stankeviciute, Simona; Aithal, Guruprasad P.; Bjornsson, Einar S.; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Sanabria-Cabrera, Judith Adriana[et al.] (Elsevier, 2021-02)
Conducting randomised clinical trials (RCTs) in idiosyncratic drug-induced liver injury (DILI) is challenging. This systematic review aims to summarise the design and findings of RCTs in the prevention and management of ... -
Prior drug allergies are associated with worse outcome in patients with idiosyncratic drug-induced liver injury: A machine learning approach for risk stratification
Niu, Hao; Solis-Muñoz, Pablo; García-Cortés, Miren; Sanabria-Cabrera, Judith Adriana; Robles-Díaz, María Mercedes; Romero-Flores, Rocío; Bonilla-Toyos, Elvira; Ortega-Alonso, Aida; Pinazo-Bandera, José M.; Cabello-Porras, María Rosario; Bessone, Fernando; Hernandez, Nelia; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Medina-Cáliz, Inmaculada; Alvarez-Alvarez, Ismael[et al.] (Elsevier, 2023-12-08)
The impact of prior drug allergies (PDA) on the clinical features and outcomes of patients who develop idiosyncratic drug-induced liver injury (DILI) is largely unknown. We aimed to assess the clinical presentation and ... -
Rechallenge in idiosyncratic drug-induced liver injury: An analysis of cases in two large prospective registries according to existing definitions
Pinazo-Bandera, José M.; Niu, Hao; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; Robles-Díaz, María Mercedes; Hernandez, Nelia; Parana, Raymundo; Nunes, Vinicius; Girala, M.; Bessone, Fernando; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren[et al.] (Elsevier, 2024-05)
Los datos sobre la reexposición positiva en la lesión hepática inducida por fármacos (DILI) idiosincrásica son escasos. Apuntamos a analizar la presentación clínica, el resultado y los fármacos asociados con la reexposición ... -
Rechallenge in idiosyncratic drug-induced liver injury: An analysis of cases in two large prospective registries according to existing definitions.
Pinazo-Bandera, Jose M.; Niu, Hao; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; Robles‑Diaz, Mercedes; Hernandez, Nelia; Parana, Raymundo; Nunes, Vinicius; Girala, Marcos; Bessone, Fernando; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren[et al.] (Elsevier, 2024)
Introduction: Data on positive rechallenge in idiosyncratic drug-induced liver injury (DILI) are scarce. We aim to analyse the clinical presentation, outcome and drugs associated with positive rechallenge in two DILI ... -
Serious liver injury induced by Nimesulide: an international collaboration study reporting 57 cases
Bessone, Fernando; Hernandez, Nelia; Mendizabal, Manuel; Ridruejo, Ezequiel; Gualano, Gisela; Fassio, Eduardo; Peralta, Mirta; Fainboim, Hugo; Anders, Margarita; Tanno, Hugo; Tanno, Federico; Parana, Raymundo; Medina-Cáliz, Inmaculada; Robles-Díaz, María Mercedes; Alvarez-Alvarez, Ismael; Niu, Hao; Stephens, Camilla; Colombato, Luis; Arrese, Marco; Reggiardo, Maria Virginia; Ono, Suzane Kioko; Carrilho, Flair; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Springer, 2021-03-24)
Nimesulide is a non-steroidal anti-inflammatory drug still marketed in many countries. We aim to analyze the clinical phenotype, outcome, and histological features of nimesulide-induced liver injury (nimesulide-DILI). We ... -
Therapeutic management of idiosyncratic drug‑induced liver injury and acetaminophen hepatotoxicity in the paediatric population: a systematic review.
Niu, Hao; Atallah, Edmond; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Aithal, Guruprasad P.; Arikan, Cigdem; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Springer Nature, 2022)
Introduction: Drug-induced liver injury (DILI) is a rare but serious adverse event that can progress to acute liver failure (ALF). The evidence for treatment of DILI in children is scarce. Objective: We aim to comprehensively ...