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Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome
Matas-Rico, Elisa; van Veen, Wouter H; Leyton-Puig, Daniela; van den Berg, Jeroen; Koster, Jan; Kedziora, Katarzyna M; Molenaar, Bas; J A Weerts, Marjolein; de Rink, Iris; Medema, René H; Giepmans, Ben N G; Perrakis, Anastassis; Jalink, Kees; Versteeg, Rogier; van Veen[et al.] (Elsevier, 2016-10)Neuroblastoma is a pediatric embryonal malignancy characterized by impaired neuronal differentiation. A better understanding of neuroblastoma differentiation is essential for developing new therapeutic approaches. GDE2 ... -
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor
Jongsma, Maikel; Matas-Rico, Elisa; Jalink, Kees; Moolenaar, Wouter H; Rzadkowski, Adrian (PLOS One, 2011-12)Lysophosphatidic acid (LPA), a lipid mediator enriched in serum, stimulates cell migration, proliferation and other functions in many cell types. LPA acts on six known G protein-coupled receptors, termed LPA1–6, showing ... -
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells
van Veen, Michiel; Matas-Rico, Elisa; van de Wetering, Koen; Leyton-Puig, Daniela; Kedziora, Katarzyna M; De Lorenzi, Valentina; Stijf-Bultsma, Yvette; van den Broek, Bram; Jalink, Kees; Sidenius, Nicolai; Perrakis, Anastassis; Moolenaar, Wouter H[et al.] (Elife, 2017-08-29)The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion. uPAR mediates degradation of the extracellular matrix ... -
Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation.
Salgado-Polo, Fernando; van Veen, Michiel; van den Broek, Bram; Jalink, Kees; Leyton-Puig, Daniela; Perrakis, Anastassis; Moolenaar, Wouter H; Matas-Rico, Elisa[et al.] (The Company of Biologist, 2020-02-10)GDE2 (also known as GDPD5) is a multispanning membrane phosphodiesterase with phospholipase D-like activity that cleaves select glycosylphosphatidylinositol (GPI)-anchored proteins and thereby promotes neuronal differentiation ...