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The C-Terminus of H-Ras as a Target for the Covalent Binding of Reactive Compounds Modulating Ras-Dependent Pathways
Oeste, Clara; Díez-Dacal, Beatriz; Bray, Francesca; García de Lacoba, Mario; G de la Torre, Beatriz; Andreu, David; Ruiz-Sánchez, Antonio Jesús; García-Dominguez, Carlota; Rojas, Jose M; Perez-Sala, Dolores[et al.] (PLOS One, 2011-01)Ras proteins are crucial players in differentiation and oncogenesis and constitute important drug targets. The localization and activity of Ras proteins are highly dependent on posttranslational modifications at their ...