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Mostrando ítems 1-6 de 6
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Inhibition of Endothelial Inflammatory Response by HT-C6, a Hydroxytyrosol Alkyl Ether Derivative.
Marrero Capitán, Ana Dácil; Castilla, Laura; Bernal, Manuel; Manrique-Poyato, María Inmaculada; Posligua-García, Joel; Moya-Utrera, Federico; Porras Alcalá, Cristina; Espartero Sánchez, José Luis; Sarabia-García, Francisco Ramón
; Rodríguez-Quesada, Ana María
; Medina-Torres, Miguel Ángel
; Martínez-Póveda, Beatriz Amparo
[et al.] (MDPI, 2023-07-28)
Hydroxytyrosol (HT) is a bioactive phenolic compound naturally present in olives and extra virgin olive oil (EVOO) which is described as an antioxidant, antitumoral and antiangiogenic molecule. Previous studies of ... -
n-Tuples on Scaffold Diversity Inspired by Drug Hybridisation to Enhance Drugability: Application to Cytarabine
García-Castro, Miguel; Fuentes-Ríos, David; López-Romero, Juan Manuel; Romero, Antonio; Moya-Utrera, Federico; Díaz-Morilla, Amelia
; Sarabia-García, Francisco Ramón
[et al.] (MDPI, 2023-12-13)
A mathematical concept, n-tuples are originally applied to medicinal chemistry, especially with the creation of scaffold diversity inspired by the hybridisation of different commercial drugs with cytarabine, a synthetic ... -
Synthesis of (-)-cannabidiol (CBD),(-)-Δ9- and(-)--Δ8-tetrahydrocannabinols, encapsulation of CBD with nanoparticles for controlled delivery and biological evaluation
Moya-Utrera, Federico; Fuentes-Ríos, David; Romero-Carrasco, Antonio; Doña Flores, Manuel; Cheng-Sánchez, Iván; Díaz-Morilla, Amelia; Pino-González, María Soledad
; Martínez-Férez, Antonio; Moreno, Javier; Mesas, Cristina; Melguizo, Consolación; Prados, José; Sarabia-García, Francisco Ramón
; López-Romero, Juan Manuel
[et al.] (Wiley, 2024-12)
Cannabidiol (CBD) is garnering increasing interest due to its significant biological activity. This natural compound is one of the major cannabinoids in Cannabis sativa L. In this work, we describe the encapsulation of CBD ... -
Synthesis, characterization and antitumor activity of a poly-4-Vinyl pyridine-co-cannabidiol polymer
Fuentes-Ríos, David; Moya-Utrera, Federico; Moreno, Javier; Mesas, Cristina; Doña Flores, Manuel; Sarabia-García, Francisco Ramón; López-Romero, Juan Manuel
; Melguizo, Consolación; Prados, José[et al.] (Elsevier, 2024)
Due to its natural origin and numerous beneficial properties, cannabidiol (CBD), one of the major phytocannabinoids of the Cannabis sativa L., has attracted the attention of many research groups in recent years. In this ... -
The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria
Porras Alcalá, Cristina; Moya-Utrera, Federico; García-Castro, Miguel; Sánchez-Ruiz, Antonio; López-Romero, Juan Manuel; Pino-González, María Soledad
; Díaz-Morilla, Amelia
; Kitamura, Seiya; W. Wolan, Dennis; Prados, Jose; Melguizo, Consolación; Cheng-Sánchez, Iván; Sarabia-García, Francisco Ramón
[et al.] (IOAP-MPDI, 2022-05-31)
The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and ... -
Transition metal-free [2,3]-sigmatropic rearrangement in the reaction of sulfur ylides with allenoates
García-Castro, Miguel; Moya-Utrera, Federico; Sarabia-García, Francisco Ramón(RSC, 2023-08)
An unprecedented transition metal free [2,3]-sigmatropic rearrangement involving stabilized sulfur ylides and allenoates has been thoroughly established. The scope and utility of this reaction have been extensively studied ...