Listar por autor "Perez-Inestrosa, Ezequiel"
Mostrando ítems 1-19 de 19
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A perspective of nanotechnology in hypersensitivity reactions including drug allergy
Montañez-Vega, María Isabel
; Ruiz-Sánchez, Antonio Jesús; Perez-Inestrosa, Ezequiel (Lippincott Williams & Wilkins, 2010-08)
Purpose of review We provide an overview of the application of the concepts of nanoscience and nanotechnology as a novel scientific approach to the area of nanomedicine related to the domain of the immune system. Particular ... -
A Turn-On Two-Photon Fluorescent Probe for Detecting Lysosomal Hydroxyl Radicals in Living Cells.
Benítez-Martín, Carlos; Guadix-Domínguez, Juan Antonio; Pearson, John; Nájera-Albendín, Francisco; Pérez-Pomares, José María; Perez-Inestrosa, Ezequiel[et al.] (Elsevier, 2019)
The detection of reactive oxygen species (ROS) in biological systems and its imaging is of great importance. Among them, the hydroxyl radical (radical dotOH) stands out as one of the most reactive, playing an important ... -
Amoxicillin Haptenation of Alpha-Enolase is Modulated by Active Site Occupancy and Acetylation.
Vida-Pol, Yolanda; Pérez-Inestrosa, Ezequiel; González Morena, Juan Manuel; Sanchez Gomez, Francisco J; Salas, María; Montañez-Vega, María Isabel; Altomare, Alessandra; Aldini, Giancarlo; Pajares, Maria Angeles; Pérez-Sala, Dolores[et al.] (Frontiers, 2022)
Allergic reactions to antibiotics are a major concern in the clinic. ß-lactam antibiotics are the class most frequently reported to cause hypersensitivity reactions. One of the mechanisms involved in this outcome is the ... -
Dendrimer surface orientation of the RGD peptide affects mesenchymal stem cell adhesion.
Vida-Pol, Yolanda; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Claros-Gil, Silvia; Becerra-Ratia, José; Andrades-Gómez, José Antonio; Pérez-Inestrosa, Ezequiel[et al.] (Royal Society of Chemistry, 2016-05-17)
Mesenchymal stem cells (MSCs) are promising candidates for a range of tissue regeneration applications. Adequate scaffolds are necessary for their application in vivo, where interactions between cells and the surface ... -
Dendritic scaffold onto titanium implants. A versatile strategy increasing biocompatibility.
Molina, Noemí; González, Ana; Monopoli, Donato; Mentado, Belinda; Becerra-Ratia, José; Santos-Ruiz, Leonor; Vida-Pol, Yolanda; Pérez-Inestrosa, Ezequiel[et al.] (MDPI, 2020-04-01)
Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally ... -
Energy-Transfer Sensitization of BODIPY Fluorescence in a Dyad with a Two-Photon Absorbing Antenna Chromophore
Dominguez-Alfaro, Antonio; Pais, Vania; Guzmán-Ríos, David; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Perez-Inestrosa, Ezequiel; Pischel, Uve[et al.] (Elsevier, 2023)
A bichromophoric dyad composed of a Prodan-derived moiety and a BODIPY dye was prepared, photophysically characterized, and tested for multiphoton fluorescence microscopy of N13 microglial cells. The dyad shows highly ... -
Extended Alkenyl and Alkynyl Benzotriazoles with enhanced Two‐Photon Absorption properties as a promising alternative to Benzothiadiazoles
Torres-Moya, Ivan; Benítez-Martín, Carlos; Donoso, Beatriz; Tardio, Carlos; Martin, Raul; Carrillo, Jose Ramon; Diaz-Ortiz, Angel; Nájera-Albendín, Francisco; Prieto, Pilar; Perez-Inestrosa, Ezequiel[et al.] (Wiley-VCH Verlag GmbH & Co, 2019)
A series of donor–p–acceptor–p–donor (D-p-A-p-D) benzoazole dyes with 2H-benzo[d][1,2,3]triazole or BTDcores have been prepared and their photophysical proper-ties characterized. The properties of these compounds dis-play ... -
Identification of an Antigenic Determinant of Clavulanic Acid Responsible for IgE‐mediated Reactions
Barbero, Nekane; Fernández-Santamaría, Rubén; Mayorga, Cristobalina; Martín-Serrano Ortiz, Ángela; Salas, Maria; Bogas, Gador; Nájera-Albendín, Francisco; Pérez-Sala, Dolores; Perez-Inestrosa, Ezequiel; Fernandez, Tahia D; Montañez-Vega, María Isabel; Torres, Maria J[et al.] (John Wiley and Sons Ltd., 2019)
Background: Selective reactions to clavulanic acid (CLV) account for around 30% of immediate reactions after administration of amoxicillin‐CLV. Currently, no immunoas‐ say is available for detecting specific IgE to CLV, ... -
Indolenine-Based Derivatives as Customizable Two-Photon Fluorescent Probes for pH Bioimaging in Living Cells
Benítez-Martín, Carlos; Guadix-Domínguez, Juan Antonio; Pearson, John; Nájera-Albendín, Francisco; Pérez-Pomares, José María; Perez-Inestrosa, Ezequiel[et al.] (American Chemical Society, 2020)
Novel pH probes based on 2-(6-methoxynaphthalen-2-yl)-3,3-dimethyl3H-indole have been synthesized and characterized. These compounds display excellent “off−on” fluorescence responses to acidic pH especially under two-photon ... -
Large-Scale Dendrimer-Based Uneven Nanopatterns for the Study of Local RGD Density Effects on Cell Adhesion
Lagunas, Anna; Castaño, Albert G; Artés, Juan M; Vida-Pol, Yolanda; Collado-Martín, Daniel; Pérez-Inestrosa, Ezequiel; Gorostiza, Pau; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Samitier, Josep[et al.] (2014)
Cell adhesion processes are governed by the nanoscale arrangement of the extracellular matrix (ECM), being more affected by local rather than global concentrations of cell adhesive ligands. In many cell-based studies, ... -
Multiepitope Dendrimeric Antigen-Silica particle composites as nano-based platforms for specific recognition of IgEs
Gil-Ocaña, Violeta; Jimenez, Isabel M.; Mayorga, Cristobalina; Doña, Inmaculada; Cespedes, Jose A.; Montañez, Maria I.; Vida-Pol, Yolanda; Torres, Maria J.; Perez-Inestrosa, Ezequiel[et al.] (Frontiers, 2021)
β-lactam antibiotics (BLs) are the drugs most frequently involved in drug hypersensitivity reactions. However, current in vitro diagnostic tests have limited sensitivity, partly due to a poor understanding of in vivo ... -
NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging.
Zanocco, Renzo P.; Nájera-Albendín, Francisco; Pérez-Inestrosa, Ezequiel; Zanocco, Antonio L.; Lemp, Else; Nonell-Marrugat, Santiago[et al.] (MDPI, 2023-05-09)
An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached ... -
New approaches for Basophil Activation Tests employing Dendrimeric Antigen-Silica Nanoparticle composites.
Calvo-Serrano, Silvia; Matamoros, Esther; Céspedes, José Antonio; Fernández-Santamaría, Rubén; Gil-Ocaña, Violeta; Pérez-Inestrosa, Ezequiel; Frecha, Cecilia; Montañez-Vega, María Isabel; Vida-Pol, Yolanda; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa[et al.] (MDPI, 2024-08-03)
In vitro detection of specific IgE bound to high-affinity receptor on basophils’ surface is 25 a widely used strategy for the evaluation of IgE-mediated immediate hypersensitivity reactions to 26 drugs. Due to the drug ... -
New Insights into Acylhydrazones E/Z isomerization: An Experimental and Theoretical Approach.
Fernández-Palacios, Sara; Matamoros, Esther; Morato Rojas, Isabel; López Navarrete, Juan T.; Ruiz-Delgado, María del Carmen; Vida-Pol, Yolanda; Perez-Inestrosa, Ezequiel[et al.] (MDPI, 2023)
A family of acylhydrazones have been prepared and characterized with the aim of investigating their potential as information storage systems. Their well stablished synthetic methodologies allowed the preparation of seven ... -
Novel probes for simultaneous dual-colour labelling of mitochondria and lysosomes.
Cellular activity depends on the accurately controlled and synchronised functions of the subcellular organelle ensemble. In this context, lysosomes and mitochondria are central to cellular metabolism as major contributors ... -
Rapid amplitude-modulation of a diarylethene photoswitch: En route to contrast-enhanced fluorescence imaging
(The Royal Society of Chemistry, 2021)A water soluble diarylethene (DAE) derivative that displays exceptionally intense fluorescence from the colorless open form has been synthesized and characterized using UV/vis spectroscopy and fluorescence microscopy. ... -
Synthesis of Amino Terminal Clicked dendrimers. Approaches to the application as a biomarker
Molina, Noemí; Nájera-Albendín, Francisco; Guadix-Domínguez, Juan Antonio; perez-pomarez, Jose M; Vida-Pol, Yolanda; Perez-Inestrosa, Ezequiel[et al.] (ACS Publications, 2019)
Herein, we present an easy and efficient synthesis of amino terminal dendrons, combining protection/deprotection reactions with copper-catalyzed azide alkyne cycloaddition in a convergent way. This new approach affords ... -
The Role of Benzylpenicilloyl Epimers in Specific IgE Recognition
Mayorga, Cristobalina; Montañez-Vega, María Isabel; Nájera-Albendín, Francisco; Bogas Herrera, Gádor; Rodriguez Gil, David; Palacios, Ricardo; Torres-Jaén, María Josefa; Vida-Pol, Yolanda; Perez-Inestrosa, Ezequiel[et al.] (Frontiers, 2021)
The high prevalence of allergy to β-lactam antibiotics is a worldwide issue. Accuracy of diagnostic methods is important to prove tolerance or allergy, with skin test considered the best validated in vivo method for ... -
Toward Two-Photon Absorbing Dyes with Unusually Potentiated Nonlinear Fluorescence Response
Benítez-Martín, Carlos; Li, Shiming; Dominguez-Alfaro, Antonio; Nájera-Albendín, Francisco; Perez-Inestrosa, Ezequiel; Pischel, Uve; Andréasson, Joakim[et al.] (American Chemical Society, 2020)
The combination of two two-photon-induced processes in a Förster resonance energy transfer (FRET)-operatedphotochromic fluorene-dithienylethene dyad lays the foundation for the observation of a quartic dependence of the ...